Polipi serrati precursori di K in soggetti coon DNA-mismatch repair
- Categoria: Oncologia
Sessile Serrated Polyps are Precursors of Colon Carcinomas With Deficient DNA Mismatch Repair.Sweetser S, Jones A, Smyrk TC, Sinicrope FA. Clin Gastroenterol Hepatol. 2016 Jul;14(7):1056-9.
We investigated whether sessile serrated adenomas/polyps (SSA/Ps) are direct precursors of colorectal carcinomas. We identified colon carcinomas that arose from SSA/Ps among 2646 colorectal cancers included in the surgical pathology database at the Mayo Clinic (2006-2012).
REBOA nel sanguinamento da varici non controllabile
- Categoria: Epatologia
Resuscitative endovascular balloon occlusion of the aorta for uncontrollable nonvariceal upper gastrointestinal bleeding.Sano H, Tsurukiri J, Hoshiai A, Oomura T, Tanaka Y, Ohta S. World J Emerg Surg. 2016 May 20;11:20.
BACKGROUND: Although resuscitative endovascular balloon occlusion of the aorta (REBOA) in various clinical settings was found to successfully elevate central blood pressure in hemorrhagic shock, this intervention is associated with high mortality and may represent a last-ditch option for trauma patients. We conducted a retrospective study of patients with nonvariceal upper gastrointestinal bleeding (UGIB) who underwent REBOA to identify the effectiveness of REBOA and reviewed published literatures.
Aumentata mortalità da ulcera peptica associata a comorbidità
- Categoria: Gastroenterologia
Increased short- and long-term mortality in 8146 hospitalised peptic ulcer patients.Malmi H, Kautiainen H, Virta LJ, Färkkilä MA. Aliment Pharmacol Ther. 2016 Aug;44(3):234-45.
BACKGROUND:Incidence and complications of peptic ulcer disease (PUD) have declined, but mortality from peptic ulcer bleeding has remained unchanged. The few recent studies on mortality associated with both uncomplicated and complicated patients with peptic ulcer disease provide contradictory results.
Sospensione di IFX associata a recidiva di RCU
- Categoria: IBD
Discontinuation of Infliximab in Patients With Ulcerative Colitis Is Associated With Increased Risk of Relapse: A Multinational Retrospective Cohort Study.Fiorino G, Cortes PN, Ellul P, Felice C, Karatzas P, Silva M, Lakatos PL, Bossa F, Ungar B, Sebastian S, Furfaro F, Karmiris K, Katsanos KH, Muscat M, Christodoulou DK, Maconi G, Kopylov U, Magro F, Mantzaris G, Armuzzi A, Boscà-Watts MM, Ben-Horin S, Bonovas S, Danese S. Clin Gastroenterol Hepatol. 2016 Jun 16. [Epub ahead of print]
BACKGROUND & AIMS:Infliximab is a safe and effective therapy for ulcerative colitis (UC). We conducted a multicenter retrospective cohort study that included 7 European countries and Israel to examine whether infliximab discontinuation can be considered for patients who achieve sustained remission.
IFX riduce il rischio di recidiva endoscopica ma non clinica nel Crohn operato
- Categoria: IBD
Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection.Regueiro M, Feagan BG, Zou B, Johanns J, Blank MA, Chevrier M, Plevy S, Popp J, Cornillie FJ, Lukas M, Danese S, Gionchetti P, Hanauer SB, Reinisch W, Sandborn WJ, Sorrentino D, Rutgeerts P; PREVENT Study Group. Gastroenterology. 2016 Jun;150(7):1568-78.
BACKGROUND & AIMS: Most patients with Crohn's disease (CD) eventually require an intestinal resection. However, CD frequently recurs after resection. We performed a randomized trial to compare the ability of infliximab vs placebo to prevent CD recurrence.