FMT intensivo utile in RCU in fase attiva
- Categoria: Gastroenterologia
Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial.Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RW, Connor S, Ng W, Paramsothy R, Xuan W, Lin E, Mitchell HM, Borody TJ. Lancet. 2017 Feb 14. [Epub ahead of print]
BACKGROUND:The intestinal microbiota is implicated in the pathogenesis of ulcerative colitis. Faecal microbiota transplantation is a novel form of therapeutic microbial manipulation, but its efficacy in ulcerative colitis is uncertain. We aimed to establish the efficacy of intensive-dosing, multidonor, faecal microbiota transplantation in active ulcerative colitis.
Nuovi biomarker delle cisti pancreatiche.
- Categoria: Pancreas e vie biliari
Novel Biomarkers for Pancreatic Cysts. Singh H, McGrath K, Singhi AD. Dig Dis Sci. 2017 Feb 14. [Epub ahead of print]
With increased utilization and ongoing advancements in cross-sectional abdominal imaging, the identification of a pancreatic cyst has become a frequent finding. While many pancreatic cysts are associated with a benign clinical course, others may transform into pancreatic ductal adenocarcinoma.
Colonscopia con Endocuff migliora identificazione di piccoli adenomi: un RCT
- Categoria: Endoscopia
Cap cuff-assisted colonoscopy versus standard colonoscopy for adenoma detection: a randomized back-to-back study.De Palma GD, Giglio MC, Bruzzese D, Gennarelli N, Maione F, Siciliano S, Manzo B, Cassese G, Luglio G. Gastrointest Endosc. 2017 Jan 9. [Epub ahead of print]
BACKGROUND AND AIMS:EndoCuff is a disposable device applied to standard colonoscopes to improve mucosal visualization. Randomized parallel trials have shown that EndoCuff increases the adenoma detection rate (ADR).
Trattamento con RF dell’HCC come bridge therapy al trapianto
- Categoria: Epatologia Oncologica
Radiofrequency Ablation of Hepatocellular Carcinoma as Bridge Therapy to Liver Transplantation: A Ten Year Intention-to-treat Analysis.Lee MW, Raman SS, Asvadi NH, Siripongsakun S, Hicks RM, Chen J, Worakitsitisatorn A, McWilliams J, Tong MJ, Finn RS, Agopian VG, Busuttil RW, Lu DS. Hepatology. 2017 Feb 7. [Epub ahead of print]
In a long-term (10 years) study of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) as bridging therapy in patients listed for orthotopic liver transplantation (LT), we evaluated the impact of RFA on waiting list dropout rate, post-LT tumor recurrence, and long-term intention to treat, disease-specific survival.
Predittori di risposta all’adalimumab in Crohn con stenosi
- Categoria: IBD
Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study.Bouhnik Y, Carbonnel F, Laharie D, Stefanescu C, Hébuterne X, Abitbol V, Nachury M, Brixi H, Bourreille A, Picon L, Bourrier A, Allez M, Peyrin-Biroulet L, Moreau J, Savoye G, Fumery M, Nancey S, Roblin X, Altwegg R, Bouguen G, Bommelaer G, Danese S, Louis E, Zappa M, Mary JY2; GETAID CREOLE Study Group. Gut. 2017 Jan 24. [Epub ahead of print]
OBJECTIVE:The efficacy of anti-tumour necrosis factors (anti-TNFs) in patients with Crohn's disease (CD) and symptomatic small bowel stricture (SSBS) is controversial. The aim of this study was to estimate the efficacy of adalimumab in these patients and to identify the factors predicting success.