Stent ricoperti associati a maggior rischio di migrazione e colecistite


Association of covered metallic stents with cholecystitis and stent migration in malignant biliary stricture.Jang S, Stevens T, Parsi M, Lopez R, Zuccaro G, Dumot J, Vargo JJ. Gastrointest Endosc. 2017 Aug 31. [Epub ahead of print]



BACKGROUND:ERCP with self-expandable metallic stent (SEMS) placement provides reliable and durable relief of malignant biliary obstruction. Our objective was to compare efficacy and adverse outcomes between uncovered SEMSs (USEMSs) and covered SEMSs (CSEMSs).

METHODS:A retrospective cohort study was performed of all consecutive patients who underwent ERCP with SEMS placement for the management of a malignant bile duct stricture. Comparative analyses on clinical success, patency duration, stent dysfunction and adverse outcomes were performed. Univariate and multivariable analyses were performed to identify factors associated with stent dysfunction.RESULTS:Six hundred forty-five patients underwent SEMS placement for the management of malignant bile duct stricture from 2008 to 2016. CSEMSs and USEMSs had similar rates of clinical success in relief of bile duct obstruction (93.0% vs. 92.1% respectively; P = 0.69) and patency duration (546.7 vs. 557.9 days, P = 0.14). Among those with intact gallbladder, the incidence of acute cholecystitis was higher in the CSEMS group compared with the USEMS group (7.8% vs 1.2%; P < 0.001). In the multivariable analysis, CSEMS use was associated with increased risk of stent migration (hazard ratio [HR] of 10.7, 95% confidence interval [CI] of 4.1-27.7).CONCLUSION:CSEMSs and USEMSs have similar clinical success rates and patency durations in management of malignant bile duct stricture. CSEMSs, however, is associated with increased rates of migration and cholecystitis. Comparable efficacy and superior safety profile of USEMSs render a compelling argument for its place as the preferred choice of SEMS in the management of malignant biliary stricture.


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