Interferon-beta-1a sottocutaneo nel trattamento della colite ulcerosa

Clinical trial: a multicentre, randomized, double-blind, placebo-controlled, dose-finding, phase II study of interferon-beta-1a in moderately active ulcerative colitis..Pena-Rossi C, Schreiber S, Golubovic G, Mertz-Nielsen A, Panes J, Rachmilewitz D, Shieh MJ, Simanenkov VI, Stanton D, Graffner H. Aliment Pharmacol Ther. 2008 Jun 21. [Epub ahead of print] Background Ulcerative colitis (UC) pathophysiology is characterized by…

Aferesi nel trattamento dell’UC

A Randomized, Double-Blind, Sham-Controlled Study of Granulocyte/Monocyte Apheresis for Active Ulcerative Colitis. Sands BE, Sandborn WJ, Feagan B, Löfberg R, Hibi T, Wang T, Gustofson LM, Wong CJ, Vandervoort MK, Hanauer S; the Adacolumn Study Group. Gastroenterology. 2008 Apr 25. [Epub ahead of print] BACKGROUND & AIMS: Activated granulocytes and monocytes/macrophages are implicated in the…

Utili gli steroidi nel distinguere la pancreatite autoimmune dal cancro del pancreas?

Is a two-week steroid trial after initial negative workup for malignancy useful in differentiating autoimmune pancreatitis from pancreatic cancer? : A prospective outcome study.   Moon SH, Kim MH, Park DH, Hwang CY, Park SJ, Lee SS, Seo DW, Lee SK. Gut. 2008 Jun 26. [Epub ahead of print]    BACKGROUND: Autoimmune pancreatitis (AIP) is a peculiar…

Metronidazolo vs vancomicina nel trattamento della sepsi da C.difficile

Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin. Al-Nassir WN, Sethi AK, Nerandzic MM, Bobulsky GS, Jump RL, Donskey CJ. Clin Infect Dis. 2008 Jul 1;47(1):56-62. BACKGROUND: There have been recent reports of frequent treatment failure associated with the use of metronidazole for treatment of Clostridium difficile-associated…

Rischio di infezione da C.difficile dopo profilassi antibiotica pre-operatoria

Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain. Carignan A, Allard C, Pépin J, Cossette B, Nault V, Valiquette L. Clin Infect Dis. 2008 Jun 15;46(12):1838-43. BACKGROUND: Perioperative antibacterial prophylaxis (PAP) is an important component of surgical site infection prevention but may…

FANS , acetaminofene e rischio di sanguinamenti GI bassi

Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada. Rahme E, Barkun A, Nedjar H, Gaugris S, Watson D. Am J Gastroenterol. 2008 Apr;103(4):872-82. BACKGROUND: The risk of upper/lower gastrointestinal (GI) adverse events associated with the concomitant use of traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) with…