Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease.Boeckxstaens GE, Beaumont H, Mertens V, Denison H, Ruth M, Adler J, Silberg DG, Sifrim D. Gastroenterology. 2010 Aug;139(2):409-17. BACKGROUND & AIMS: Transient lower esophageal sphincter relaxations (TLESRs) are a major mechanism behind reflux. This study assessed the effects of…
L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis–a randomized and controlled clinical trial.Malaguarnera M, Gargante MP, Russo C, Antic T, Vacante M, Malaguarnera M, Avitabile T, Li Volti G, Galvano F. Am J Gastroenterol. 2010 Jun;105(6):1338-45. OBJECTIVES: Nonalcoholic steatohepatitis (NASH) is a known metabolic disorder of the liver. No treatment has…
Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis.West NJ, Clark SK, Phillips RK, Hutchinson JM, Leicester RJ, Belluzzi A, Hull MA. Gut. 2010 Jul;59(7):918-25. OBJECTIVE: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) has anticolorectal cancer activity in vitro and in preclinical models.
Paris criteria are effective in diagnosis of primary biliary cirrhosis and autoimmune hepatitis overlap syndrome. Kuiper EM, Zondervan PE, van Buuren HR. Clin Gastroenterol Hepatol. 2010 Jun;8(6):530-4. Epub 2010 Mar 19. BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) differ in clinical, laboratory, and histologic features as well as in response to therapy.…
Role of EUS-FNA-Based Cytology in the Diagnosis of Mucinous Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis.Thosani N, Thosani S, Qiao W, Fleming JB, Bhutani MS, Guha S. Dig Dis Sci. 2010 Aug 6. [Epub ahead of print] BACKGROUND: Preoperative diagnosis of malignancy in pancreatic cystic lesions (PCLs) remains challenging. Most non-mucinous cystic lesions (NMCLs) are…
Cognitive function does not worsen during long-term low-dose peginterferon therapy in patients with chronic hepatitis C.Fontana RJ, Bieliauskas LA, Back-Madruga C, Lindsay KL, Litman HJ, Lok AS, Kronfol Z; HALT-C Trial Group. Am J Gastroenterol. 2010 Jul;105(7):1551-60. Epub 2010 Jan 26. OBJECTIVES: Neuropsychiatric toxicity is a common dose-limiting side effect of interferon therapy. The primary aim…