Sospensione di Clopidogrel non necessaria prima della polipectomia

Postpolypectomy bleeding in patients undergoing colonoscopy on uninterrupted clopidogrel therapy. Singh M, Mehta N, Murthy UK, Kaul V, Arif A, Newman N. Gastrointest Endosc. 2010 May;71(6):998-1005. Epub 2010 Mar 11.  BACKGROUND: The risk of postpolypectomy bleeding (PPB) in patients undergoing colonoscopy on uninterrupted clopidogrel therapy has not been established. OBJECTIVE: To assess the PPB rate and…

Variabilità del rischio di sanguinamento UGI associato all’assunzione di diversi tipi di FANS

Variability of risk of upper gastrointestinal bleeding among nonsteroidal anti-inflammatory drugs.González EL, Patrignani P, Tacconelli S, Rodríguez LA. Arthritis Rheum. 2010 Feb 22. [Epub ahead of print] OBJECTIVES:: Traditional nonsteroidal anti-inflammatory drugs(tNSAIDs) increase the risk of gastrointestinal bleeding/perforation(UGIB) but the magnitude of this effect for coxibs in the general population and the degree of variability across…

Meta-analisi dei tassi di sopravvivenza nell’HCC non trattato

A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma. Cabibbo G, Enea M, Attanasio M, Bruix J, Craxì A, Cammà C.Hepatology. 2010 Apr;51(4):1274-83. Knowing the spontaneous outcome of hepatocellular carcinoma (HCC) is important for designing randomized controlled trials (RCTs) of new therapeutic approaches; however, survival of patients in the absence…

Fattori predittivi di fallimento dell’infliximab dopo sospensione dell’AZA

Predictors of infliximab failure after azathioprine withdrawal in Crohn’s disease treated with combination therapy. Oussalah A, Chevaux JB, Fay R, Sandborn WJ, Bigard MA, Peyrin-Biroulet L. Am J Gastroenterol. 2010 May;105(5):1142-9.  OBJECTIVES: Whether all Crohn’s disease (CD) patients should maintain long-term azathioprine treatment in combination with infliximab remains controversial. We analyzed the predictive factors of…

Stent metallici nel K colon : severe le complicazioni long term

Severe complications limit long-term clinical success of self-expanding metal stents in patients with obstructive colorectal cancer.Fernández-Esparrach G, Bordas JM, Giráldez MD, Ginès A, Pellisé M, Sendino O, Martínez-Pallí G, Castells A, Llach J. Am J Gastroenterol. 2010 May;105(5):1087-93. Epub 2009 Nov 24. OBJECTIVES: Self-expanding metal stents (SEMS) are increasingly being used to treat malignant colorectal obstruction.…