PPI e rischio di infezione da C.difficile

Proton pump inhibitors and risk for recurrent Clostridium difficile infection.Linsky A, Gupta K, Lawler EV, Fonda JR, Hermos JA. Arch Intern Med. 2010 May 10;170(9):772-8. BACKGROUND: Proton pump inhibitors (PPIs) are widely used gastric acid suppressants, but they are often prescribed without clear indications and may increase risk of Clostridium difficile infection (CDI). We sought to…

HCC non resecabile : opportuna l’indicazione al trapianto

Patients with unresectable hepatocellular carcinoma beyond milan criteria: should we perform transarterial chemoembolization or liver transplantation? Kim JM, Kwon CH, Joh JW, Kim SJ, Shin M, Kim EY, Moon JI, Jung GO, Choi GS, Lee SK. Transplant Proc. 2010 Apr;42(3):821-4.   Patients with unresectable, beyond Milan criteria, hepatocellular carcinoma (HCC) invariably undergo palliative transarterial chemoembolization…

Colonscopia ad alta definizione reduce il numero di missed-adenomas

High-definition colonoscopy detects colorectal polyps at a higher rate than standard white-light colonoscopy. Buchner AM, Shahid MW, Heckman MG, McNeil RB, Cleveland P, Gill KR, Schore A, Ghabril M, Raimondo M, Gross SA, Wallace MB. Clin Gastroenterol Hepatol. 2010 Apr;8(4):364-70.  BACKGROUND & AIMS: Adenoma detection rates might be improved through use of high-definition colonoscopy, which…

Terapia di mantenimento RCU : efficace monosomministrazione giornaliera di 5-ASA a rilascio prolungato

Once-daily dosing of delayed-release oral mesalamine (400-mg tablet) is as effective as twice-daily dosing for maintenance of remission of ulcerative colitis. Sandborn WJ, Korzenik J, Lashner B, Leighton JA, Mahadevan U, Marion JF, Safdi M, Sninsky CA, Patel RM, Friedenberg KA, Dunnmon P, Ramsey D, Kane S. Gastroenterology. 2010 Apr;138(4):1286-96, 1296.e1-3. BACKGROUND & AIMS: The…

La chirurgia antireflusso non previene lo sviluppo di adenocarcinoma

The risk of esophageal adenocarcinoma after antireflux surgery.Lagergren J, Ye W, Lagergren P, Lu Y. Gastroenterology. 2010 Apr;138(4):1297-301.  BACKGROUND & AIMS: The question of a possible preventive effect of antireflux surgery on the development of esophageal or cardia adenocarcinoma remains unsettled. We aimed to clarify whether antireflux surgery prevents later development of esophageal adenocarcinoma.