Multicenter external validation of the ABCD2 score in triaging TIA patients.Tsivgoulis G, Stamboulis E, Sharma VK, Heliopoulos I, Voumvourakis K, Teoh HL, Patousi A, Andrikopoulou A, Lim EL, Stilou L, Sim TB, Chan BP, Stefanis L, Vadikolias K, Piperidou C. Neurology. 2010 Apr 27;74(17):1351-7. OBJECTIVES: A simple clinical score (ABCD(2) score) has been introduced to triage…
The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease. Würtz M, Grove EL, Kristensen SD, Hvas AM. Heart. 2010 Mar;96(5):368-71. Epub 2009 Nov 11. OBJECTIVE: To evaluate the effect of proton pump inhibitors (PPIs) on the platelet response to aspirin in patients with coronary artery disease (CAD). DESIGN:…
Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, Parkin DM, Wardle J, Duffy SW, Cuzick J; UK Flexible Sigmoidoscopy Trial Investigators. Lancet. 2010 May 8;375(9726):1624-33. BACKGROUND: Colorectal cancer is the third most common cancer worldwide and has…
Institute of Medicine recommendations for the prevention and control of hepatitis B and C.Mitchell AE, Colvin HM, Palmer Beasley R. Hepatology. 2010 Mar;51(3):729-33. Despite federal, state, and local public health efforts to prevent and control hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, these diseases remain serious health problems in the United States. About…
Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding risk.Schelleman H, Bilker WB, Brensinger CM, Wan F, Yang YX, Hennessy S. Am J Med. 2010 Feb;123(2):151-7. PURPOSE: To evaluate whether initiation of a fibrate or statin increases the risk of hospitalization for gastrointestinal bleeding in warfarin users.
Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study.Colucci G, Labianca R, Di Costanzo F, Gebbia V, Cartenì G, Massidda B, Dapretto E, Manzione L, Piazza E, Sannicolò M, Ciaparrone M, Cavanna L, Giuliani F, Maiello E, Testa A, Pederzoli…