Meta-analisi: alte dosi vs dosi standard di PPI nei sanguinamenti alti

High-dose vs non-high-dose proton pump inhibitors after endoscopic treatment in patients with bleeding peptic ulcer: a systematic review and meta-analysis of randomized controlled trials.Wang CH, Ma MH, Chou HC, Yen ZS, Yang CW, Fang CC, Chen SC. Arch Intern Med. 2010 May 10;170(9):751-8. BACKGROUND: High-dose proton pump inhibitors (PPIs) (80-mg bolus, followed by 8-mg/h continuous infusion…

M.di Crohn moderato-severo: Infliximab, AZA o terapia di combinazione ?

Infliximab, azathioprine, or combination therapy for Crohn’s disease.Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, Lichtiger S, D’Haens G, Diamond RH, Broussard DL, Tang KL, van der Woude CJ, Rutgeerts P; SONIC Study Group. N Engl J Med. 2010 Apr 15;362(15):1383-95.  BACKGROUND: The comparative efficacy and safety of infliximab and azathioprine therapy…

M.di Crohn : mucosal healing = remissione sostenuta

Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn’s disease.Baert F, Moortgat L, Van Assche G, Caenepeel P, Vergauwe P, De Vos M, Stokkers P, Hommes D, Rutgeerts P, Vermeire S, D’Haens G; Belgian Inflammatory Bowel Disease Research Group; North-Holland Gut Club. Gastroenterology. 2010 Feb;138(2):463-8 BACKGROUND & AIMS: Few prospective data are available to…

PPI e anti-H2 associati ad aumentato rischio di fratture dell’anca

Proton Pump Inhibitors and Histamine-2 Receptor Antagonists are Associated with Hip Fractures among At-Risk Patients. Corley DA, Kubo A, Zhao W, Quesenberry C. Gastroenterology. 2010 Mar 27. [Epub ahead of print] BACKGROUND & AIMS:: Drugs that inhibit gastric acid might increase the risk of hip fracture. However, little long-term exposure data exist and no large studies…

Anamnesi familiare e rischio CCR : a constellation approach

Population-based family history-specific risks for colorectal cancer: a constellation approach.Taylor DP, Burt RW, Williams MS, Haug PJ, Cannon-Albright LA. Gastroenterology. 2010 Mar;138(3):877-85. Epub 2009 Dec 21.  BACKGROUND & AIMS: Colorectal cancer (CRC) risk estimates based on family history typically include only close relatives. We report familial relative risk (FRR) in probands with various combinations, or constellations,…