Clopidogrel + PPI :impatto sull’outcome e mortalità cardiovascolare

Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Rassen JA, Choudhry NK, Avorn J, Schneeweiss S. Circulation. 2009 Dec 8;120(23):2322-9.   BACKGROUND: Recent studies have raised concerns about the reduced efficacy of clopidogrel when used concurrently with proton pump inhibitors (PPIs), but those studies…

Trattamento delle meta epatiche da k colon con embolizzazione della porta

Impact of portal vein embolization on long-term survival of patients with primarily unresectable colorectal liver metastases.Wicherts DA, de Haas RJ, Andreani P, Sotirov D, Salloum C, Castaing D, Adam R, Azoulay D.Br J Surg. 2010 Feb;97(2):240-50. BACKGROUND:: Portal vein embolization (PVE) increases the resectability of initially unresectable colorectal liver metastases (CLM). This study evaluated long-term survival…

Vitamina D e rischio di K colon

Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study.Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJ, Norat T, Pischon T, Jansen EH, Slimani N, Byrnes G, Rinaldi S, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Morois S, Kaaks R, Linseisen J, Boeing…

Management dei sanguinamenti alti non varicosi

International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding.Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P; International Consensus Upper Gastrointestinal Bleeding Conference Group. Ann Intern Med. 2010 Jan 19;152(2):101-13. DESCRIPTION: A multidisciplinary group of 34 experts from 15 countries developed this update and expansion of the…

Second-look + terapia termica previene rebleeding: una meta-analisi

Second-look endoscopy with thermal coagulation or injections for peptic ulcer bleeding: A meta-analysis.Tsoi KK, Chan HCh, Chiu PW, Pau CY, Lau JY, Sung JJ. J Gastroenterol Hepatol. 2010 Jan;25(1):8-13.  Abstract Background and Aims: In the management of peptic ulcer bleeding, the benefits of second-look endoscopic treatment with thermal coagulation or injections in controlling recurrent bleeding is…

Placebo superiore all’antidepressivo SJW nel trattamento dell’IBS

A randomized, double-blind, placebo-controlled trial of St John’s wort for treating irritable bowel syndrome.Saito YA, Rey E, Almazar-Elder AE, Harmsen WS, Zinsmeister AR, Locke GR, Talley NJ. Am J Gastroenterol. 2010 Jan;105(1):170-7.  OBJECTIVES: St John’s wort (SJW) is known to effectively treat patients with mild-to-moderate depression. Antidepressants are frequently used to treat irritable bowel syndrome (IBS).…