Polimorfismo IL-28B utile per personalizzare il trattamento nei pazienti HCV+ genotipo 2-3

An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response.Mangia A, Thompson AJ, Santoro R, Piazzolla V, Tillmann HL, Patel K, Shianna KV, Mottola L, Petruzzellis D, Bacca D, Carretta V, Minerva N, Goldstein DB, McHutchison JG. Gastroenterology. 2010 Sep;139(3):821-7, 827.e1. Epub…

Aferesi e RCU : una review sistematica

Systematic review: granulocyte/monocyte adsorptive apheresis for ulcerative colitisS. Thanaraj, P. J. Hamlin, A. C. Ford. Alimentary Pharmacology & TherapeuticsArticle first published online: 14 OCT 2010 Background Patients with ulcerative colitis (UC) that is chronically active despite 5-aminosalicylates or immunomodulators, or who are dependent on corticosteroids to maintain remission, have limited treatment options. Granulocyte/monocyte adsorptive apheresis (GMAA)…

Shock settico: β-lattamici+ macrolidi o aminoglicosidici associati a migliore prognosi

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis.Kumar A, Zarychanski R, Light B, Parrillo J, Maki D, Simon D, Laporta D, Lapinsky S, Ellis P, Mirzanejad Y, Martinka G, Keenan S, Wood G, Arabi Y, Feinstein D, Kumar A, Dodek P, Kravetsky L, Doucette S; Cooperative Antimicrobial…

TAO non riduce accuratezza del FOBT

Prevalence of significant neoplasia in FOBT-positive patients on warfarin compared with those not on warfarin.Iles-Shih L, Collins JF, Holub JL, Lieberman DA. Am J Gastroenterol. 2010 Sep;105(9):2030-4; OBJECTIVES: The fecal occult blood test (FOBT) is widely used for colorectal cancer screening. However, the impact of warfarin use on FOBT sensitivity and specificity remains unclear. This…

IBD fattore di rischio per VTE ricorrente

  Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism.Novacek G, Weltermann A, Sobala A, Tilg H, Petritsch W, Reinisch W, Mayer A, Haas T, Kaser A, Feichtenschlager T, Fuchssteiner H, Knoflach P, Vogelsang H, Miehsler W, Platzer R, Tillinger W, Jaritz B, Schmid A, Blaha B, Dejaco C, Eichinger S. Gastroenterology. 2010…