Metaboliti AZA predittori di remissione dell’epatite autoimmune

 Clinical significance of azathioprine metabolites for the maintenance of remission in autoimmune hepatitis.Dhaliwal HK, Anderson R, Thornhill EL, Schneider S, McFarlane E, Gleeson D, Lennard L. Hepatology. 2012 Oct;56(4):1401-8. doi: 10.1002/hep.25760. Epub 2012 Sep 7. Azathioprine (AZA) is used to maintain remission in autoimmune hepatitis (AIH), but up to 18% of patients are unresponsive. AZA is…

Resection rate per K colon dimunite del 4% anno grazie allo screening

 Proximal and distal colorectal cancer resection rates in the United States since widespread screening by colonoscopy.Myer PA, Mannalithara A, Singh G, Ladabaum U. Gastroenterology. 2012 Nov;143(5):1227-36.  BACKGROUND and AIMS: Screening decreases colorectal cancer (CRC) incidence and mortality. Colonoscopy has become the most common CRC screening test in the United States, but the degree to which…

Budesonide MMX efficace nel trattamento di RCU

 Once-Daily Budesonide MMX® Extended-Release Tablets Induce Remission in Patients With Mild to Moderate Ulcerative Colitis: Results From the CORE I Study.Sandborn WJ, Travis S, Moro L, Jones R, Gautille T, Bagin R, Huang M, Yeung P, Ballard ED 2nd. Gastroenterology. 2012 Nov;143(5):1218-1226 BACKGROUND and  AIMS: Budesonide is a corticosteroid with minimal systemic corticosteroid activity due to…

Statine riducono rischio di HCC

 Statins Are Associated with a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-Analysis.Singh S, Singh PP, Singh AG, Murad MH, Sanchez W. Gastroenterology. 2012 Oct 11. BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Several studies have shown that statins could have chemopreventive effects on HCC. We…

Trattamento conservativo della necrosi pancreatica: una meta-analisi

 Efficacy of Conservative Treatment, without Necrosectomy, for Infected Pancreatic Necrosis – A Systematic Review and Meta-Analysis.Mouli VP, Sreenivas V, Garg PK. Gastroenterology. 2012 Oct 11.  BACKGROUND & AIMS: Conservative treatment (intensive care, a combination of antimicrobial agents, and nutritional support, with or without drainage of the infected fluid) has recently been shown to be effective…