Endoscopic snare papillectomy: a possible radical treatment for a subgroup of T1 ampullary adenocarcinomas.Petrone G, Ricci R, Familiari P, Inzani F, Matsuoka M, Mutignani M, Delle Fave G, Costamagna G, Rindi G. Endoscopy. 2013;45(5):401-4. doi: 10.1055/s-0032-1326213. Epub 2013 Apr 24.
Pancreaticoduodenectomy is the standard care for invasive ampullary adenocarcinomas. However, endoscopic snare papillectomy (ESP) might play a curative role in very selected patients. We studied a series of 15 patients with T1 ampullary adenocarcinoma who were treated by ESP alone and followed up for a mean of 29.6 ± 21.9 months (range 8 – 81 months).
ESP was curative for eight patients (57.1 %). No tumor-related death was observed in patients with a cancer infiltration depth of ≤ 4 mm. According to this preliminary experience, we suggest that this measurable variable threshold should be considered as a possible basis for future large-scale studies.