Safety and efficacy of early feeding based on clinical assessment at 4 hours after ERCP: a prospective randomized controlled trial.Park CH, Jung JH, Hyun B, Kan HJ, Lee J, Kae SH, Jang HJ, Koh DH, Choi MH, Chung MJ, Bang S, Park SW. Gastrointest Endosc. 2017 Sep 27. [Epub ahead of print]
BACKGROUND AND AIMS:The optimal timing of refeeding after ERCP is unknown. Some practices keep fasting for 24 hours after ERCP whereas others resume feeding earlier. We aimed to evaluate the risk of post-ERCP pancreatitis (PEP) in patients who initiate early feeding based on their clinical assessment, including serum amylase testing, performed at 4 hours after ERCP.
METHODS:Patients who were scheduled for ERCP were recruited. Patients without abdominal pain and tenderness and a serum amylase level within 1.5-fold the upper limit of normal (ULN) at 4 hours after ERCP were randomly assigned to either 4-hour fasting or 24-hour fasting group. Patients from the 4-hour fasting group started oral intake 4 hours after ERCP, whereas those from the 24-hour fasting group fasted for 24 hours after ERCP.RESULTS:Among the 276 enrolled, PEP was identified in 3 (2.2%) from the 4-hour fasting group and in 5 (3.6%) from the 24-hour fasting group, with a rate difference of -1.4% (one-sided 97.5% confidence interval, -∞-2.5%). Four-hour fasting was non-inferior to 24-hour fasting in terms of PEP incidence. The total medical costs for treatment-related ERCP was significantly lower in the 4-hour fasting group than in the 24-hour fasting group (1,157.2±311.9 vs 1,311.2±410.7 U.S. dollars, P=0.032).CONCLUSION:Early feeding in patients without abdominal pain and tenderness, and a serum amylase level <1.5-fold the ULN at 4 hours after ERCP does not increase PEP incidence after ERCP and decreases medical costs.