UNA MAGNIFICA INTRODUZIONE alla NETWORK MEDICINE SULL’ULTIMO NUMERO DI “FORWARD” (Il Pensiero Scientifico)

Network medicine: una metafora che abbatte le barriere fra le discipline Una nuova consapevolezza nello studio delle malattie, le quali diventano sistemi complessi di relazioni in evoluzione dinamica Sebastiano Filetti, Lorenzo Farina Sapienza università di Roma Per rendere l’idea del cambiamento moderno del paradigma scientifico dominante in medicina potremmo senz’altro affermare – con linguaggio giuridico – che…

EBM ED ESAME OBIETTIVO: E’ TEMPO DI INSERIRE L’ULTRASONOGRAFIA

Time to Add a Fifth Pillar to Bedside Physical Examination: Inspection, Palpation, Percussion, Auscultation, and Insonation Jagat Narula, MD, PhD1; Y. Chandrashekhar, MD2; Eugene Braunwald, MD3 JAMA Cardiol. 2018;3(4):346-350.  Abstract Inspection, palpation, percussion, and auscultation have been the 4 pillars of clinical bedside medicine. Although these basic methods of physical examination have served us well, traditional bedside examination, for a number of reasons including diminishing…

STATINE IN PREVENZIONE PRIMARIA: LE 5 LINEE GUIDA CON NNT

Statin Use in Primary Prevention of Atherosclerotic Cardiovascular Disease According to 5 Major Guidelines for Sensitivity, Specificity, and Number Needed to Treat Martin Bødtker Mortensen, MD, PhD1,2; Børge Grønne Nordestgaard, MD, DMSc2,3 JAMA Cardiol. Published online October 2, 2019. doi:10.1001/jamacardio.2019.3665 Key Points Question  How does the number needed to treat to prevent 1 atherosclerotic cardiovascular disease event compare among 5 major statin…

EFFETTI COLLATERALI DEGLI ANTIDEPRESSIVI: UNA “UMBRELLA” REVIEW

Association of Antidepressant Use With Adverse Health OutcomesA Systematic Umbrella Review Elena Dragioti, PhD1,2; Marco Solmi, MD, PhD3,4,5; Angela Favaro, MD, PhD3,4; et al JAMA Psychiatry. Published online October 2, 2019. doi:10.1001/jamapsychiatry.2019.2859 Key Points Question  Is antidepressant use associated with adverse health outcomes, and how credible is the evidence behind this association in published meta-analyses of real-world data? Findings  In this systematic umbrella review of 45 meta-analyses…