POVERA EBM: I DUBBI SULL’ULTIMO TRIAL ANTI COVID-19. RIDUZIONE DELLA MORTALITA’ DEL 77% ? DA “SCIENCE”

‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality Robert F. Service Science’s COVID-19 reporting is supported by the Heising-Simons Foundation. It would be the best news by far in COVID-19 treatment: According to a preprint published on 22 June, an experimental prostate cancer drug named proxalutamide reduced deaths…

LE NUOVE TERAPIE PER LA OBESITA’. UN PUNTO DI VISTA IN 2 PAGINE SU JAMA

Progress in Pharmacotherapy for Obesity Susan Z. Yanovski et al. The obesity epidemic in the US continues unabated. The elevated risk for severe disease and death from COVID-19 associated with obesity and its comorbidities underscores the urgency to develop and implement effective prevention and treatment strategies. Multicomponent behavior-based weight management interventions are recommended for adults…

DIAGNOSI E TERAPIA DELLA MALATTIA EPATICA DA ALCOL: UNA REVISIONE DA JAMA

Diagnosis and Treatment of Alcohol-Associated Liver Disease A Review Ashwani K. Singal, MD; Philippe Mathurin, MD IMPORTANCE Alcohol-associated liver disease results in cirrhosis in approximately 10% to 20% of patients. In 2017, more than 2 million people had alcohol-associated cirrhosis in the US. Alcohol-associated liver disease is the primary cause of liver-related mortality and the…

INTRODUZIONE ALLA ANALISI STATISTICA DEI DATI CLINICI IN 15′ MINUTI! PROVARE PER CREDERE

Statistical Analysis of Biomedical Data — an Overview From p-values and regression to clustering and classification Sukanta Saha The last decade has seen an enormous boom in the production of patient data. From wearables like smartwatches logging our heart rates to RNA sequencing for differential expression, our ability to monitor and observe individual patients’ health…

I TEST DI DIAGNOSI PER LA FIBROSI NELLA NAFLD: UNA META-ANALISI PER DATI INDIVIDUALI PER RIDURRE LE BIOPSIE

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis Ferenc Emil Mózes et al. ABSTRACT Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement…

GLI INIBITORI DELLA POMPA PROTONICA “PROTEGGONO” DAL DIABETE ? UNA IPOTESI ED UNA META-ANALISI INTERESSANTE

Effects of Proton Pump Inhibitors on Glycemic Control and Incident Diabetes: A Systematic Review and Meta-Analysis Carol Chiung-Hui Peng  et al. Abstract Context Whether proton pump inhibitors (PPI) can improve glycemic control among individuals with diabetes or decrease the risk of incident diabetes in the general population is unclear. Objective To evaluate the impact of…