NUOVI “TARGET” PER LA COLESTASI E LA STEATOSI. UNA GRANDE REVISIONE DA “GUT” (FREE!)

Novel therapeutic targets for cholestatic and fatty liver disease Michael Trauner , Claudia Daniela Fuchs Abstract Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key pathophysiological mechanisms which can be targeted by novel therapeutic concepts that are currently developed for both areas. Nuclear receptors (NRs) are ligand-activated transcriptional regulators of key metabolic processes including hepatic…

MALATTIA DIVERTICOLARE : UN EDITORIALE EVIDENCE-BASED 2020 DA DIS COLON RECTUM

Evidence-Based Management of Diverticular Disease: What’s New and What’s Missing? David R. Flum, • Thomas E. Read   IT seems the more we learn about diverticulitis, the less we know. In this month’s Diseases of the Colon & Rectum, “The American Society of Colon and Rectal Surgeons (ASCRS) Clinical Practice Guidelines for the Treatment of…

MICROBIOMA E TERAPIE INDIVIDUALIZZATE: IL FUTURO E’ GIA’ QUI ! UNA REVISIONE DA “NATURE GASTRO&HEPATOL”

The promise of the gut microbiome as part of individualized treatment strategies Daniel A. Schupack, et al. Abstract Variability in disease presentation, progression and treatment response has been a central challenge in medicine. Although variability in host factors and genetics are important, it has become evident that the gut microbiome, with its vast genetic and…

COME DIAVOLO SPIEGARE QUANTO E’ BASSA LA PROBABILITA’ DI COMPLICAZIONI DA VACCINO ANTI COVID-19 ? IL CASO DELLA TROMBOSI POST-VACCINO AL CONFRONTO CON DECESSO DA ANESTESIA, MORTALITA’ SUL LAVORO O DA INCIDENTE STRADALE

Understanding one in 100,000 What does this tiny probability look like? Anthony B. Masters The EMA stated there was a plausible link between the Oxford-AstraZeneca (Vaxzevria) vaccine and rare blood clots. The European Medicines Agency said the probability of this kind of blood clot was “very low”. With millions vaccinated, very rare side effects can emerge. The Paul-Ehrlich-Institut reported…

DIVERTICOLITE SIGMOIDEA: UNA REVISIONE DAL WORLD J. OF GASTROENTEROLOGY

Update on the management of sigmoid diverticulitis Mark H Hanna, Andreas M Kaiser Abstract Diverticular disease and diverticulitis are the most common non-cancerous pathology of the colon. It has traditionally been considered a disease of the elderly and associated with cultural and dietary habits. There has been a growing evolution in our understanding and the…