MA COS’E’ ‘STA “TRIAL SEQUENTIAL ANALYSIS” ? UNA OTTIMA SEMPLICE INTRODUZIONE DA RICERCATORI ITALIANI SU UN NUOVO PARADIGMA (FREE)

METODOLOGIA, REAL WORLD EVIDENCE, Senza categoria

Trial sequential analysis: plain and simple Alessandro De Cassai et al. The use of trial sequential analysis (TSA) in the medical literature is increasing in recent times. However, not all readers may be familiar with this statistical technique. This correspondence aims to provide readers with the essentials to understand and interpret TSA. Adequately conducted meta-analyses…

DIVERTICOLITE: UNA GUIDA PRATICA DALLA AGA. UNA REVISIONE TRA ESPERTI 2021

CHIRURGIA, GASTROENTEROLOGIA, LINEE GUIDA EBM, MALATTIA DIVERTICOLARE, MEDICI DI FAMIGLIA, MEDICINA INTERNA, Senza categoria

AGA Clinical Practice Update on Medical Management of Colonic Diverticulitis: Expert Review Anne F Peery et al. Abstract Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictably and can lead to chronic gastrointestinal symptoms. Gastroenterologists commonly care for patients with this disease. The purpose of this Clinical Practice Update is to provide practical and…

PERCHE’ E’NECESSARIO CONFRONTARE IL TASSO DI DECESSI TRA VACCINATI E NON-VACCINATI: UNA RIFLESSIONE PER GLI AMICI NO-VAX DA “OUR WORLD IN DATA” (FREE)

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNA, METODOLOGIA, Senza categoria

Why we need to compare the rates of death between vaccinated and unvaccinated During a pandemic, you might see headlines like “Half of those who died from the virus were vaccinated”. It would be wrong to draw any conclusions about whether the vaccines are protecting people from the virus based on this headline. The headline is not…

I NUOVI AGENTI ANTIVIRALI PER IL COVID-19: UNA OTTIMA RIFLESSIONE DA “NATURE REVIEWS” (FREE)

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNA

A tale of two antiviral targets — and the COVID-19 drugs that bind them The FDA is considering authorizations for Pfizer’s paxlovid and Merck & Co.’s molnupiravir, the first two oral COVID-19 antivirals. Megan Cully COVID-19, for all of the problems it has created, has shown the unprecedented speed with which drug developers can move.…

IL GRAVE PROBLEMA DELLA RIPRODUCIBILITA’ (Reproducibility Project: Cancer Biology): SOLO IL 26% DEGLI ESPERIMENTI PRECLINICI IN ONCOLOGIA RISULTA RIPETIBILE (FREE)

METODOLOGIA, ONCOLOGIA

Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology Timothy M Errington et al. Abstract We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of preclinical research in cancer biology. The initial aim of the project was to repeat 193 experiments from 53 high-impact papers, using an approach in which the experimental…