GRADE EXPERT INVITANO AD UNA CORRETTA QUANTIFICAZIONE DELLA “CERTAINTY OF EVIDENCE” . LOOK AT THE FIGURES !

GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings Linan Zeng et al. Abstract Objective : To provide practical principles and examples to help GRADE users make optimal choices regarding their ratings of certainty of evidence using a minimally or partially contextualized approach. Study Design and Setting : Based on the…

PLACEBO EFFECT: UNA GRANDE REVIEW

Pain, placebo, and test of treatment efficacy: a narrative review Lene Vase 1, Karolina Wartolowska 2 Abstract Over the past decade, the mechanisms underlying placebo effects have begun to be identified. At the same time, the placebo response appears to have increased in pharmacological trials and marked placebo effects are found in neurostimulation and surgical trials, thereby posing…

COVID-19: QUALE TERAPIA ANTI-TROMBOTICA? UNA REVISIONE DEI TRIAL DELLA ASS.AMERICANA DEI CARDIOLOGI

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 JACC State-of-the-Art Review Azita H. Talasaz et al. Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of…

LA ASSUNZIONE DI PPI RIDUCE LA RISPOSTA ALLA TERAPIA ANTI-HCV !

Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV/HCV coinfection on ledipasvir/sofosbuvir: a real‐world study from a multicentre VA cohort Tzu‐Hao Lee et al. Abstract Previous studies have reported an association of proton pump inhibitor (PPI) use and decreased sustained viral response rate (SVR) in patients taking ledipasvir/sofosbuvir (LDV/SOF). The relationship…

UNA OTTIMA SCHEDA DI JAMA SUI VACCINI ANTI COVID-19

SARS-CoV-2 Vaccines C. Buddy Creech, MD, MPH; Shannon C. Walker, MD; Robert J. Samuels, MBChB Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its prefusion [native] conformation) was identified as the immunodominant antigen of the virus.1 Evaluation of patients with SARS-CoV-2 revealed that binding and neutralizing…

QUALE DIETA E’ ANTI-INFIAMMATORIA ?

Long-term dietary patterns are associated with proinflammatory and anti-inflammatory features of the gut microbiome Laura A Bolte et al. Abstract Objective The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions…