IL PLASMA DA CONVALESCENTI E’ DI DUBBIA UTILITA’ PER I PAZIENTI CON COVID-19. UNA META-ANALISI

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19A Systematic Review and Meta-analysis Perrine Janiaud et al. Key PointsQuestion  Is treatment with convalescent plasma associated with improved clinical outcomes? Findings  In a meta-analysis of 4 peer-reviewed and published randomized clinical trials including 1060 patients with COVID-19 treated with convalescent plasma vs control, the risk ratio…

DUE DECENNI DI RICERCA PER IL CANCRO DEL PANCREAS: QUALE GUADAGNO?

Two decades of research toward the treatment of locally advanced and metastatic pancreatic cancer: Remarkable effort and limited gain CelineYeh et al. Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is diagnosed at the locally advanced or metastatic stage in approximately 80% of cases. Relative to other tumor types, progress in the treatment…

TERAPIA ECOENDOSCOPICA PER I TUMORI PANCREATICI: UNA GRANDE REVISIONE

Endoscopic ultrasound-guided therapies for pancreatic solid tumors: An overview Alberto LarghI et al. ABSTRACT The close proximity of the endoscopic ultrasound (EUS) probe to the pancreas, coupled with the ease with which a needle can be inserted into a pancreatic lesion, have contributed to the development of EUS-guided therapies for both adenocarcinoma and neuroendocrine pancreatic neoplasms.…

GESTIONE NON-CHIRURGICA DELLA DIVERTICOLITE COMPLICATA CON ASCESSO: UNA REVISIONE SISTEMATICA

Failure of nonoperative management in patients with acute diverticulitis complicated by abscess: a systematic review Hayley Fowler et al. Abstract Background: The aim of this study was to assess failure rates following nonoperative management of acute diverticulitis complicated by abscess and trends thereof. Method: Pubmed, MEDLINE, EMBASE, CINAHL, Cochrane Library, and Web of Science were systematically searched.…

CAMBIO SIMILARI NELLE IBD: INTERCAMBIABILITA’ NON EQUIVALE AD INTECAMBIABILE

The Automatic Substitution of Biosimilars: Definitions of Interchangeability are not Interchangeable Anita Afzali et al. Abstract In the USA, an interchangeability designation provides biosimilar sponsors with a pathway for achieving what is standard for small-molecule generics: pharmacy-level auto-substitution for an innovator. No other major health authority links interchangeability to automatic substitution, as all require the…