REPLICAZIONE DEGLI STUDI CONTROLLATI NELLA “REAL WORLD EVIDENCE”: UN OTTIMO EDITORIALE

Replication of Randomized, Controlled Trials Using Real-World Data: What Could Go Wrong? David Thompson1 Abstract With the growing interest in using real-world evidence (RWE) for regulatory purposes, researchers and policy makers are considering how best to assess the credibility of RWE. Because the randomized controlled trial (RCT) has long been regarded as the gold standard…

TRIAL VERSUS “REAL WORLD EVIDENCE”: THE DUPLICATE INITIATIVE. UN PRIMO CONFRONTO SU STUDI IN CARDIOLOGIA E DIABETOLOGIA

Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies: First Results From the RCT DUPLICATE Initiative Jessica M Franklin et al. Abstract Background: Regulators are evaluating the use of noninterventional real-world evidence (RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE initiative (Randomized, Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques…

PER UNA MIGLIORE TRASPARENZA DEGLI STUDI DI “REAL WORLD EVIDENCE”: THE RWE TRANSPARENCY INITIATIVE

Improving Transparency to Build Trust in Real-World Secondary Data Studies for Hypothesis Testing-Why, What, and How: Recommendations and a Road Map from the Real-World Evidence Transparency Initiative Lucinda S Orsin et al Abstract Real-world data (RWD) and the derivations of these data into real-world evidence (RWE) are rapidly expanding from informing healthcare decisions at the…

GLI STUDI DI “REAL WORLD EVIDENCE” PER IL DIABETE: UNA GUIDA

Conducting real-world evidence studies on the clinical outcomes of diabetes treatments Sebastian Schneeweiss et al. Abstract Real-world Evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data from the routine operation of the healthcare system, is thought to complement evidence on the efficacy of medications from RCTs. RWE studies follow…

LIVELLI PLASMATICI DEI DOA: CHE UTILITA’ CLINICA ?

Direct Oral Anticoagulants Plasma Levels Measurement: Clinical Usefulness from Trials and Real-World Data Francesca Renon 1, et al Abstract Measurement of direct oral anticoagulants (DOACs) activity is not routinely necessary. Indeed, evaluation of DOACs plasmatic concentration is discouraged for the majority of patients, due to the lack of outcome data supporting this approach. Nevertheless, DOAC measurements…

LE 243 REVISIONI SISTEMATICHE E META-ANALISI SUL COVID-19 SONO DI QUALITA’ RIDOTTA !

Reporting and methodological quality of COVID-19 systematic reviews needs to be improved: an evidence mapping Yanfei Li et al. Abstract Objectives : To assess the reporting and methodological quality of COVID-19 systematic reviews, and to analyze trends and gaps in the quality, clinical topics, author countries, and populations of the reviews using an evidence mapping…