PPI RIDUCONO EFFICACIA DI INFLIXIMAB NELLE IBD: UN’ OTTIMA META-ANALISI

The influence of proton pump inhibitor therapy on the outcome of infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies Thomas X Lu et al. Abstract Objective In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton…

LINEE GUIDA AGA 2021 DIVERTICOLITE

CLINICAL PRACTICE UPDATES AGA Clinical Practice Update on Medical Management of Colonic Diverticulitis: Expert Review Anne F. Peery et al. Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictably and can lead to chronic gastrointestinal symptoms. Gastroenterologists commonly care for patients with this disease. The purpose of this Clinical Practice Update is to provide…

ED ILSISTEMA NERVOSO ENTERICO? UNA GRANDE REVIEW

Disorders of the enteric nervous system — a holistic view Beate Niesler et al Abstract The enteric nervous system (ENS) is the largest division of the peripheral nervous system and closely resembles components and functions of the central nervous system. Although the central role of the ENS in congenital enteric neuropathic disorders, including Hirschsprung disease…

NEI PAZIENTI RICOVERATI CON COVID REMDESIVIR, IROSSICLOROCHINA, LOPINAVIR ED INTERFERONE BETA NON RIDUCONO LA MORTALITA’.

In inpatients with COVID-19, none of remdesivir, hydroxychloroquine, lopinavir, or interferon b -1a differed from standard care for in-hospital mortality Pan H, Peto R, et al. Question: In adults hospitalized with coronavirus disease 2019 (COVID-19), what are the effects of 4 antiviral drugs compared with local standard care without the antivirals on in-hospital mortality? Design:…

CLIPPING PER EMORRAGIA ACUTA SEVERA DA DIVERTICOLI: QUALE RUOLO? E DOPO PULIZIA?

Severe Acute Colonic Diverticular Bleeding: The Efficacy of Rapid Bowel Preparation With 1 L Polyethylene Glycol Ascorbate Solution and Direct Endoscopic Hemoclipping for Successful Hemostasis Adnan Malik, et al. ABSTRACT Colonic diverticular bleeding is an established cause of painless acute lower gastrointestinal hemorrhage. Colonoscopy, performed within 24 hours of presentation, is the usual initial diagnostic…

ANTIBIOTICI “DISTRUGGONO” IL MICROBIOTA INTESTINALE: UNA BUONA REVIEW

Antibiotics as Major Disruptors of Gut Microbiota Jaime Ramirez et al. Advances in culture-independent research techniques have led to an increased understanding of the gut microbiota and the role it plays in health and disease. The intestine is populated by a complex microbial community that is organized around a network of metabolic interdependencies. It is…