FDA AUTORIZZA IN EMERGENZA L’USO DI TOCILIZUMAB NEI PAZIENTI OSPEDALIZZATI PER COVID-19

Coronavirus (COVID-19) Update: FDA Authorizes Drug for Treatment of COVID-19 Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the drug Actemra (tocilizumab) for the treatment of hospitalized adults and pediatric patients (2 years of age and older) who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation,…

GLI ANTAGONISTI DELLA IL-6 RIDUCONO LA MORTALITA’ DA COVID-19 NEGLI OSPEDALIZZATI: UNA META-ANALISI DAL GRUPPO WHO

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19. A Meta-analysis The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group Key PointsQuestion  Is administration of IL-6 antagonists associated with 28-day all-cause mortality in patients hospitalized for COVID-19? Findings  This prospective meta-analysis of 27 randomized trials included 10 930 patients, of whom 2565…

POVERA EBM: I DUBBI SULL’ULTIMO TRIAL ANTI COVID-19. RIDUZIONE DELLA MORTALITA’ DEL 77% ? DA “SCIENCE”

‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality Robert F. Service Science’s COVID-19 reporting is supported by the Heising-Simons Foundation. It would be the best news by far in COVID-19 treatment: According to a preprint published on 22 June, an experimental prostate cancer drug named proxalutamide reduced deaths…

LE NUOVE TERAPIE PER LA OBESITA’. UN PUNTO DI VISTA IN 2 PAGINE SU JAMA

Progress in Pharmacotherapy for Obesity Susan Z. Yanovski et al. The obesity epidemic in the US continues unabated. The elevated risk for severe disease and death from COVID-19 associated with obesity and its comorbidities underscores the urgency to develop and implement effective prevention and treatment strategies. Multicomponent behavior-based weight management interventions are recommended for adults…

DIAGNOSI E TERAPIA DELLA MALATTIA EPATICA DA ALCOL: UNA REVISIONE DA JAMA

Diagnosis and Treatment of Alcohol-Associated Liver Disease A Review Ashwani K. Singal, MD; Philippe Mathurin, MD IMPORTANCE Alcohol-associated liver disease results in cirrhosis in approximately 10% to 20% of patients. In 2017, more than 2 million people had alcohol-associated cirrhosis in the US. Alcohol-associated liver disease is the primary cause of liver-related mortality and the…

INTRODUZIONE ALLA ANALISI STATISTICA DEI DATI CLINICI IN 15′ MINUTI! PROVARE PER CREDERE

Statistical Analysis of Biomedical Data — an Overview From p-values and regression to clustering and classification Sukanta Saha The last decade has seen an enormous boom in the production of patient data. From wearables like smartwatches logging our heart rates to RNA sequencing for differential expression, our ability to monitor and observe individual patients’ health…