REAL WORLD EVIDENCE : EVENTI TROMBOTICI DOPO VACCINO ASTRA NELLA POPOLAZIONE DELLA NORVEGIA E DANIMARCA

Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study Anton Pottegård et al. Objective To assess rates of cardiovascular and haemostatic events in the first 28 days after vaccination with the Oxford-AstraZeneca vaccine ChAdOx1-S in Denmark and Norway and to compare them with rates…

CHEMOPREVENZIONE CANCRO COLO-RETTALE: UNA “EXPERT REVIEW” DALL’AMERICAN GASTROENTEROLOGICAL ASSOCIATION

AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia: Expert Review Peter S. Liang et al. DESCRIPTION: The purpose of this expert review is to describe the role of medications for the chemoprevention of colorectal neoplasia. Neoplasia is defined as precancerous lesions (e.g., adenoma and sessile serrated lesion) or cancer. The scope of this review…

CLOSTRIDIODIES DIFFICILE: LE NUOVE LINEE GUIDA DELL’AMERICAN COLLEGE OF GASTROENTEROLOGY

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections Colleen R. Kelly, et al. Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to the management of adults with C. difficile infection and represent the official practice recommendations of…

RIFAXIMINA NELLA CIRROSI: UN’OTTIMA REVIEW DEL GRUPPO INTERNAZIONALE CON PAOLO CARACENI E PAOLO ANGELI

The Use of Rifaximin in Patients With Cirrhosis Paolo Caraceni et al. Abstract Rifaximin is an oral nonsystemic antibiotic with minimal gastrointestinal absorption and broad-spectrum antibacterial activity covering both gram-positive and gram-negative organisms. Rifaximin is currently used worldwide in patients with cirrhosis for preventing recurrent HE because its efficacy and safety have been proven by…

IL CONCETTO DI “NET BENEFIT” : OCCHIO A TUTTI GLI OUTCOME!

The Net Benefit of a treatment should take the correlation between benefits and harms into account Marc Buyse et al. Highlights • The assessment of benefits and harms from experimental treatments often ignores the association between outcomes • The method of generalized pairwise comparisons (GPC) takes into account the association between endpoints • A Net…

I PROBIOTICI DI PROSSIMA GENERAZIONE: UNA MAGNIFICA REVIEW ! (ANCHE CONTRO IL COVID-19?)

Next-Generation Probiotics and Their Metabolites in COVID-19 Thomas Gautier et al. Abstract: Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and gastrointestinal dysfunctions suggesting the spread of…