NUOVA META-ANALISI SULLA ERADICAZIONE DELL’ HELICOBACTER PYLORI PER LA DISPEPSIA. EFFETTO DI MIGLIORAMENTO CONFERMATO, MA MODESTO: NNT 14!

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis Alexander C Ford et al. Abstract Objective: Functional dyspepsia (FD) is a chronic disorder that is difficult to treat. Helicobacter pylori may contribute to its pathophysiology. A Cochrane review from 2006 suggested that eradication therapy was beneficial, but there have been numerous randomised controlled trials (RCTs)…

I TRIAL A BRACCIO SINGOLO ACCELERANO LA APPROVAZIONE DI FDA. MA SONO A FORTE RISCHIO DI BIAS E PRESENTANO EFFETTO RIDOTTO.

Single-arm clinical trials that supported FDA Accelerated Approvals have modest effect sizes and at high risk of bias Tatiane Bomfim Ribeiro et al. Highlights • Single-arm trials that informed treatment approval by the FDA-AA have modest effect sizes • The lower bound of the 95% CI of 53% of approved treatments crossed the line of…

TRENT’ANNI DI EBM: UN COMMENTO DI GIULIO FORMOSO SU “RECENTI PROGRESSI IN MEDICINA” (FREE)

Trent’anni di EBM: cosa è cambiato, cosa deve ancora cambiare Giulio Formoso Riassunto. In generale, medicina basata sulle prove e pratica clinica non devono essere viste come due entità in contrapposizione. La prima suggerisce alcune regole per la realizzazione e la interpretazione degli studi, con l’obiettivo di migliorare la salute del maggior numero possibile di…

UNA NUOVA MODALITA’ DI PRESENTARE L’INCERTEZZA! DAL “BMJ CLINICAL EVIDENCE”

Density strips: visualisation of uncertainty in clinical data summaries and research findings Christopher J Weir , Adrian W Bowman Abstract The disproportionate focus on statistical significance in reporting and interpreting clinical research studies contributes to publication bias and encourages selective reporting. This highlights a need for alternative approaches that clearly communicate the uncertainty in the…

LA REPLICAZIONE DEGLI STUDI E’ NEL FUTURO DELLA EBM. E’ DIFFICILE, MA ESSENZIALE. DA “NATURE” (FREE)

Replicating scientific results is tough — but essential A high-profile replication study in cancer biology has obtained disappointing results. Scientists must redouble their efforts to find out why. Replicabillity — the ability to obtain the same result when an experiment is repeated — is foundational to science. But in many research fields it has proved…