RISCHIO DI DIVERTICOLITE: DIETA E MARCATORI DI INFIAMMAZIONE SUGGERISCONO UN SOTTOGRUPPO DI PAZIENTI CHE MERITA LA PREVENZIONE FARMACOLOGICA. DA “CLINICAL GASTRO&HEPATOLOGY”

Association Between Inflammatory Diets, Circulating Markers of Inflammation, and Risk of Diverticulitis Wenjie Ma et al. BACKGROUND & AIMS: Lifestyle and dietary risk factors for diverticulitis also have been associated with chronic inflammation. We performed a prospective study of associations among the inflammatory potential of diets, circulating markers of inflammation, and the incidence of diverticulitis.…

LA DIAGNOSI PRECOCE DEL CANCRO DEL PANCREAS VIA ANALISI DEL MICROBIOMA FECALE: L’EDITORIALE DI “GUT” (FREE)

Finding clues in unexpected places: detection of pancreatic cancer through the faecal microbiome Rachel Newsome AND Christian Jobin Pancreatic cancer is an intractable form of cancer that ranks as the 12th most common cancer worldwide (2.7%) but alarmingly is predicted to increase in the next two decades.1 Pancreatic ductal adenocarcinoma (PDAC) is the most common form…

DIAGNOSI PRECOCE DEL CANCRO DEL PANCREAS: UN MARCATORE FECALE AD ALTA SPECIFICITA’ : AUROC 0.94. DA “GUT” (FREE)

A faecal microbiota signature with high specificity for pancreatic cancer   Ece Karta et al. Abstract Background Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and salivary microbiota as potential diagnostic biomarkers. Methods We applied shotgun metagenomic and 16S rRNA amplicon sequencing to samples from…

NASH: UNA REVISIONE SISTEMATICA SULLE ULTIME TERAPIE. DA “LANCET” : PRIMO NOME ALBERTO MANTOVANI (VERONA)

Efficacy of peroxisome proliferator-activated receptor agonists, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors for treatment of non-alcoholic fatty liver disease: a systematic review Alessandro Mantovani  et al. There are no licensed treatments for non-alcoholic fatty liver disease (NAFLD), but three different classes of antihyperglycaemic drugs—peroxisome proliferator-activated receptor (PPAR) agonists, glucagon-like peptide-1 receptor (GLP-1R) agonists,…

MORBO DI CROHN: PER LE STENOSI MEGLIO LA DILATAZIONE CON PALLONE O L’INSERIMENTO DI PROTESI? UN OTTIMO TRIAL.

Self-expandable metal stents versus endoscopic balloon dilation for the treatment of strictures in Crohn’s disease (ProtDilat study): an open-label, multicentre, randomised trial Carme Loras et al.   Background Endoscopic balloon dilation (EBD) is the established endoscopic treatment for short strictures in Crohn’s disease. Fully covered self-expandable metal stents (FCSEMS) have been used for endoscopic treatment…

COME COMUNICARE IL RISULTATO DI UN TEST DI DIAGNOSI AL PAZIENTE. E COME COMUNICARE L’INCERTEZZA DEL RISULTATO! DA “JAMA” (FREE)

Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence Maria R. Dahm, MA, PhD1; Carmel Crock, MBBS, BLit Uncertainty pervades the diagnostic process. In health care, taxonomies of uncertainty have been developed to describe aspects such as personal (eg, individual knowledge gaps), scientific (eg, limits of biomedical knowledge), and probabilistic (eg, imprecise estimates of risk or prognosis) dimensions of uncertainty.1  …