The Gut-Lymph Model Gives New Treatment Strategies for Organ Failure John A. Windsor et al. Organ Failure Remains an Unmet Global Challenge Each year, more than 20 million people with organ failure (OF) are admitted to intensive care units around the world.1 With a 30% mortality rate, it remains the leading cause of death in intensive…
Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Updated Modeling Study for the US Preventive Services Task Force Steven P. Dehmer et al. Abstract Importance The US Preventive Services Task Force (USPSTF) is updating its 2016 recommendation on the use of aspirin for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC). Objective To provide…
USPSTF Report on Aspirin for Primary Prevention Donald M. Lloyd-Jones As with many therapies in modern medicine, aspirin for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) is neither all good nor all bad. Specifically, aspirin may benefit selected patients, but that comes at the price of a narrower therapeutic window than desirable because of the…
Risk of gastrointestinal bleeding with concomitant NOAC and glucocorticoid treatment Abstract Overview of: Holt A, Blanche P, Zareini B, et al. Gastrointestinal bleeding risk following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants. Heart. doi:10.1136/heartjnl-2021-319503 [Epub ahead of print 13 Aug 2021]. Key learning points The risk of gastrointestinal (GI) bleeding when oral glucocorticoids…
From info-desert to info-demic: the role of independent drug bulletins David Phizackerley James A Cave n the late 1950s and early 1960s independent drug bulletins first began to be published. At that time, laws on the licensing of medicines had yet to be introduced, there was little effective control of marketing and promotion of medicines,…
Two new oral antivirals for covid-19: ▼molnupiravir and ▼nirmatrelvir plus ritonavir Abstract This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial…