REVISIONI SISTEMICHE E REPLICABILITA’. ATTENZIONE : REPRODUCIBILITY IS ARRIVING! UNA LETTERA IMPORTANTE DAL “J.OF CLINICAL EPIDEMIOLOGY” (FREE)

METODOLOGIA, REAL WORLD EVIDENCE, Senza categoriaLascia un commento

Replicability in the context of systematic reviews: A call for a framework with considerations regarding duplication, overlap, and intentionality Livia Puljak, Dawid Pieper Letter to the editor Reproducibility and replicability are considered central to the development and evolution of science, as they should ensure the efficient generation of reliable knowledge [[1. Much has been written…

ENCEFALOPATIA SEVERA EPATICA: L-ORNITINA L-ASPARTATO OLTRE LATTULOSIO/RIFAXIMINA? GUADAGNO SULLA MORTALITA’ – 25%. UN TRIAL IN DOPPIO CIECO DA “HEPATOLOGY”.

CIRROSI EPATICA, EPATOLOGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, Senza categoriaLascia un commento

L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial Arpan Jainet al. Abstract Background and Aims: Data on the use of intravenous L-ornithine Laspartate (LOLA) in the treatment of overt HE (OHE) is limited. We evaluated the role of intravenous LOLA in patients of cirrhosis with OHE grade III–IV. Approach…

GESTIONE CHIRURGICA DELLA NECROSI PANCREATICA. UNA GRANDE REVIEW DA”JAMA SURGERY” (FREE)

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Contemporary Surgical Management of Pancreatic Necrosis Lydia R. Maurer, MD, MPH; Peter J. Fagenholz, MD Abstract Importance  For decades, infected or symptomatic pancreatic necrosis was managed by open surgical necrosectomy, an approach that has now been largely supplanted by an array of techniques referred to as the step-up approach. Observations  This review describes the evidence base behind the…

LA REVIEW DI”LANCET” SUI VACCINO ANTICANCRO A BASE DI mRNA. GRANDE. DA LEGGERE SUBITO! (FREE)

EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, INTERNATIONAL SNAPSHOTS, MEDICINA INTERNA, ONCOLOGIA, Senza categoriaLascia un commento

Clinical advances and ongoing trials of mRNA vaccines for cancer treatment Cathrine Lund Lorentzen et al. Summary Years of research exploring mRNA vaccines for cancer treatment in preclinical and clinical trials have set the stage for the rapid development of mRNA vaccines during the COVID-19 pandemic. Therapeutic cancer vaccines based on mRNA are well tolerated,…