Target trial emulation: applying principles of randomised trials to observational studies
Anthony A Matthews et al.
“using observational data to emulate a target trial”
The need for target trial emulation
Observational studies can provide evidence on the effectiveness of interventions when randomised trials are not feasible because they are expensive, unethical, or take too long. Causal inference using observational data is, however, challenging; not only are observational studies prone to confounding bias due to the lack of randomisation, but incorrect study design choices (such as the specification of the start of follow-up) can also cause self-inflicted biases.1 Such study design flaws can be overcome by first designing a hypothetical randomised trial—the target trial—that would answer the question of interest, then emulating this target trial using the available observational data and appropriate methodology.23
LEGGI TUTTO https://www.bmj.com/content/378/bmj-2022-071108?utm_source=TrendMD&utm_medium=cpc&utm_campaign=BMJ%27s_Coronavirus_(covid-19)_Hub_TrendMD_1#:~:text=https%3A//doi.org/10.1136/bmj%2D2022%2D071108