LIVELLI EMATICI DI ENDOTOSSINA: BIOMARCATORI DELLA PROGRESSIONE DELLA NASH. UNA IMPEGNATIVA META-ANALISI DA “CLINICAL GASTROENTEROLOGY & HEPATOLOGY” (FREE).

Blood endotoxin levels as biomarker of non-alcoholic fatty liver disease: a systematic review and meta-analysis Josefin Soppert et al. Abstract Background and Aims: Growing evidence supports a role of gut-derived metabolitesin non-alcoholic fatty liver disease (NAFLD), but the relation of endotoxin levels with gut permeability and NAFLD stage remains unclear. This systematic review with meta-…

E’ UTILE IL NUOVO TRIAL? UN NUOVO TOOL PER EVITARE SPRECHI NELLA RICERCA ! ABBIAMO DA IMPARARE DAI GINECOLOGY! MA IOANNIDIS COLPISCE ANCORA ! DA”BJOG” (FREE).

Assessing the usefulness of randomized trials in obstetrics and gynaecology Janneke van ‘t Hooft et al. Health care professionals will be familiar with how little of what they read in medical journals is of direct value (useful) to their practice.(1) Randomized controlled trials (RCTs) are traditionally at the top of the evidence validity hierarchy for…

ACALASIA : LA MIOTOMIA ENDOSCOPICA PERORALE APPARE SICURA ! UNA OTTIMA REVISIONE SISTEMATICA ITALIANA. DA “ENDOSCOPY”.

Long-term outcomes of peroral endoscopic myotomy for achalasia: a systematic review and meta-analysis Edoardo Vespa et al. Abstract Background The long-term outcomes of esophageal peroral endoscopic myotomy (POEM) are still unknown. Methods We searched electronic databases (MEDLINE/PubMed, EMBASE, Scopus) for studies assessing outcomes after POEM for esophageal achalasia with a minimum median follow-up duration of 36 months.…

EMORRAGIA DIGESTIVA SUPERIORE. QUALE SCORE E’ PIU’ VALIDO? UN CONFRONTO TRA I DIVERSI TOOL. NON MALE ANCHE IL GLORIOSO PNED SCORE ITALIANO! VERSO UN NUOVO SCORE? DA “DIGESTIVE AND LIVER DISEASE”

Comparison of assessment tools in acute upper gastrointestinal bleeding: Which one at which time point? Riccardo Marmo et al. Abstract Background Decisions on managing bleeders remain a critical issue due to the high death risk. The Glasgow-Blatchford score (GBS) correctly identifies low-risk patients but none of the existing scores precisely assess the high risk patients.…

DIPENDENZA DA ALCOL. LE NUOVE (OTTIME) LINEE GUIDA DAL CANADA (FREE).

Canada’s Guidance on Alcohol and Health: Final Report This document was published by the Canadian Centre on Substance Use and Addiction (CCSA). Paradis, C. et al. About this Document This report contains three documents produced for three different target groups. Public Summary The Public Summary is a one-page summary intended for the general public. Technical…

IL MICROBIOTA RESPONSABILE DEL FALLIMENTO DELLA TERAPIA CON 5-ASA NELLE IBD? OCCHIO AL REPORT DA “IBD” (FREE)

GUT MICROBIAL METABOLISM OF 5-ASA IS PROSPECTIVELY ASSOCIATED WITH TREATMENT FAILURE IN PATIENTS WITH IBD  Raaj Mehta et al. Abstract BACKGROUND Variation in clinical response to 5-aminosalicylic acid (5-ASA) has been attributed in part to its inactivation by gut microbes. Recently, in the Inflammatory Bowel Disease (IBD) Multi’omics Database (IBDMDB), a multicenter year-long cohort of…