Yuval Noah Harari argues that artificial intelligence has hacked the operating system of human civilization. Fears of artificial intelligence (AI) have haunted humanity since the dawn of the computer age. Until now these fears have focused on machines using physical means to kill, enslave or replace humans. But in the last two years, new artificial…
Meta-Analysis of Randomized Clinical Trials on Long-Term Outcomes of Surgical Treatment of Perforated Diverticulitis Horesh, Nir et al. Abstract Objective: Assess long-term outcomes of patients with perforated diverticulitis treated with resection or laparoscopic lavage (LL). Summary Background Data: Surgical treatment of perforated diverticulitis changed in the last few decades. LL and increasing evidence that primary anastomosis (PRA) is feasible in certain patients have broadened…
Emerging issues in probiotic safety: 2023 perspectives Daniel Merenstein et al. ABSTRACT Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics into vulnerable populations, warrants concise, and actionable recommendations on…
Peer review before trial conduct could increase research value and reduce waste Maximilian Siebert , Florian Naudet , and John P.A. Ioannidis Highlights ° Traditional peer-review of clinical trials happens after the trials are already done ° In this piece we examine several options for review and improvement of trials before they are conducted ° Innovative ideas are necessary…
Guidance to best tools and practices for systematic reviews Kat Kolaski1, Lynne Romeiser Logan, and John P. A. Ioannidis Abstract Data continue to accumulate indicating that many systematic reviews are methodologically fawed, biased, redundant, or uninformative. Some improvements have occurred in recent years based on empirical methods research and standardization of appraisal tools; however, many authors do not…