ATTENZIONE ! L’USO DEI BIOLOGICI PER IL CROHN: LE ULTIME LINEE GUIDA DEL GRUPPO IG-IBD! DA” Digestive and Liver Disease ” (FREE)

Use of biologics for the management of Crohn’s disease: IG-IBD clinical guidelines based on the GRADE methodology Fabio Salvatore Macaluso et al per Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD), Working panel, Review panel A cure for Crohn’s disease (CD), a chronic inflammatory disease of the gastrointestinal tract of unknown etiology, is…

EFFETTO DEL BIFIDOBACTERIUM SULLA GLICEMIA: UNA ATTENTA META-ANALISI NON EVIDENZIA RIDUZIONI NELL’UOMO. DA “Advances in Nutrition” (FREE)

The Effects of Bifidobacterium Probiotic Supplementation on Blood Glucose: A Systematic Review and Meta-Analysis of Animal Models and Clinical Evidence Emily P. Van Syoc et al. Abstract Probiotic supplementation is a potential therapeutic for metabolic diseases, including obesity, metabolic syndrome (MetS), and type 2 diabetes (T2D), but most studies deliver multiple species of bacteria in addition to…

PROBIOTICI E PROFILO LIPIDICO NELLA NASH: UNA OTTIMA “UMBRELLA REVIEW” CON META-ANALISI. DA “Systematic Reviews” (FREE)

Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study Amirhossein Naghipour et al. Abstract Background Non-alcoholic fatty liver disease (NAFLD), the most common liver disease, is closely associated with metabolic conditions such as obesity and diabetes mellitus, which significantly impact human health outcomes. The impaired…

IL TIMING PER LA COLECISTECTOMIA DOPO PANCREATITE BILIARE. L’INTERVENTO PRECOCE ENTRO 14 GG PUO’ COMPORTARE UN AUMENTO DELLA MORTALITA’. UN GRANDE STUDIO ITALIANO RETROSPETTIVO. DA “JAMA SURGERY”

Timing of Cholecystectomy After Moderate and Severe Acute Biliary Pancreatitis Marcello Di Martino et al. IMPORTANCE Considering the lack of equipoise regarding the timing of cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP), it is critical to assess this issue. OBJECTIVE To assess the outcomes of early cholecystectomy (EC) in patients…

LA GRAN PARTE DEI 23.000 TRIAL REGISTRATI NEL COCHRANE DATABASE HA CONCLUSIONI LARGAMENTE SOVRAVALUTATE: VERSO UNA RILETTURA DEL POTERE DEL “P VALUE” ! DA “NEJM Evid “

A New Look at P Values for Randomized Clinical Trials Erik van Zwet, et al. Abstract BACKGROUND We have examined the primary efficacy results of 23,551 randomized clinical trials from the Cochrane Database of Systematic Reviews. METHODS We estimate that the great majority of trials have much lower statistical power for actual effects than the…