TOFACITINIB RIDUCE LE COMPLICANZE OPERATORIE RISPETTO AI BIOLOGICI IN CASO DI COLECTOMIA PER COLITE ULCEROSA. UN IMPORTANTE STUDIO MULTICENTRICO ITALIANO RETROSPETTIVO DA “AJG”.

Rates of adverse events in patients with ulcerative colitis undergoing colectomy during treatment with tofacitinib vs biologics: a multicenter observational study Dragoni, Gabriele and the “TOFA-poSTOP” Study Group Abstract Background and aims: Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the risk of post-operative complications…

LA DIVERSITA’ DEL MICROBIOMA PROTEGGE DAI PATOGENI BLOCCANDO LA LORO NUTRIZIONE ! UNA CONFERMA DA “SCIENCE”

Microbiome diversity protects against pathogens by nutrient blocking FRANCES SPRAGGE ET AL. Microbiome diversity protects against pathogens by nutrient blocking. Pathogens (red) fail to colonize when they overlap with the community (yellow and green bacteria) in nutrient-utilization profiles (nutrient niches are indicated by colored circles). As microbiome diversity increases, the probability that different nutrients are consumed…

MANIFESTAZIONI EXTRAINTESTINALI DELLE IBD: LE NUOVE LINEE GUIDA 2024 “ECCO”. DA “JCC” (FREE)

ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease  Hannah Gordon et al. 1. Introduction This is the second European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and anaemia.1 Up to 50% of patients with IBD will develop at least one EIM, which may impact each body…

“WALLED-OFF NECROSIS” DEL PANCREAS. METAL VS PLASTIC STENTS SONO COMPARABILI. UNA BUONA META-ANALISI DAGLI USA. DA”ENDOSCOPY”

Treatment of walled-off necrosis using lumen-apposing metal stents versus plastic stents: a systematic review and meta-analysis of data from randomized trials JYoung Bang et al. Abstract Background: Walled-off necrosis (WON) is highly morbid disease most effectively managed by endoscopic drainage with lumen-apposing metal stents (LAMSs) or plastic stents, with or without necrosectomy. This meta-analysis compared…

COLITE ULCEROSA ACUTA SEVERA : AGGIUNGETE TOFACITINIB ALLO STEROIDE ! UN IMPORTANTE TRIAL MONOCENTRICO DA “AMERICAN JOURNAL OF GASTROENTEROLOGY”

Tofacitinib in Acute Severe Ulcerative Colitis (TACOS): A Randomized Controlled Trial Arshdeep Singh et al. Abstract Introduction: Intravenous corticosteroids are the mainstay of treatment of patients hospitalized with acute severe ulcerative colitis (ASUC). However, 30%-40% of the patients are refractory to corticosteroids. We investigated whether addition of tofacitinib to corticosteroids improved the treatment responsiveness in patients…