UN ANALOGO DELL’ORMONE FGF19, LA ALDAFERMINA, E’ UN BUON CANDIDATO PER LA NASH+CIRROSI ! UN TRIAL IN DOPPIO CIECO DA “HEPATOLOGY” (FREE)

A randomized, double-blind, placebo-controlled trial of aldafermin in patients with NASH and compensated cirrhosis Rinella, Mary E et al. Abstract Background and Aims: Aldafermin, an engineered analog of the human hormone FGF19, improves liver histology in patients with noncirrhotic NASH; however, its efficacy and safety in compensated cirrhosis is unknown. No drug has yet to…

IL FUSOBACTERIUM NUCLEATUM DELLA BOCCA PASSA NELL’INTESTINO E PROVOCA IL CANCRO DEL COLON ? UN GRANDE ARTICOLO DA “NATURE” (FREE).

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche Martha Zepeda-Rivera et al. Abstract Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals1, is enriched in human colorectal cancer (CRC) tumours2,3,4,5. High intratumoral Fn loads are associated with recurrence, metastases and poorer patient…

PROCINETICI: UN’OTTIMA REVIEW DALLA SOCIETA’ EUROPEA ED AMERICANA DI NEUROGASTROENTEROLOGY SU 6 CLASSI DI FARMACI. DA “Neurogastroenterology & Motility”.

Prokinetics-safety and efficacy: The European Society of Neurogastroenterology and Motility/The American Neurogastroenterology and Motility Society expert review Serhat Bor et al. Abstract Background: Prokinetics are a class of pharmacological drugs designed to improve gastrointestinal (GI) motility, either regionally or across the whole gut. Each drug has its merits and drawbacks, and based on current evidence as…

K PANCREAS AVANZATO : IL TRIAL “CROSSFIRE”. E’ UTILE LA RADIOTERAPIA STEREOTATTICA ABLATIVA VIA RISONANZA IN CORSO DI FOLFIRINOX ?

MRI-guided stereotactic ablative body radiotherapy versus CT-guided percutaneous irreversible electroporation for locally advanced pancreatic cancer (CROSSFIRE): a single-centre, open-label, randomised phase 2 trial Florentine E F Timmer, et al. Summary Background Pancreatic ductal adenocarcinoma is an aggressive disease with a dismal prognosis. Stage III locally advanced pancreatic cancer is considered unresectable and current palliative chemotherapy…

ABLAZIONE LOCALE DEL K PANCREAS. DOVE SIAMO: POCHE RISPOSTE, ANCORA MOLTE DOMANDE. UN EDITORIALE DA “LANCET GASTROENTEROLOGY&HEPATOLOGY” DOPO IL TRIAL “CROSSFIRE”

Local ablation in pancreatic cancer: some answers and more questions editorial by Zachary T Berman , Rebekah R White There is no consensus on how to treat patients with locally advanced pancreatic cancer beyond systemic chemotherapy. A minority of patients will respond well and become candidates for surgical resection, and many will die from distant disease progression.…

OCCHIO ALLA NUTRIZIONE NEI NOSTRI PAZIENTI PIU’ GRAVI! 10 RACCOMANDAZIONI DA “CRITICAL CARE” (FREE)

Personalized nutrition therapy in critical care: 10 expert recommendations Paul E. Wischmeyer et al Abstract Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose enteral nutrition (EN) or parenteral nutrition (PN) can be started within 48 h of admission. While…