LA PERSISTENZA SOTTO TERAPIA PER LE IBD PREMIA USTEKINUMAB E VEDOLIZUMAB. UN’OTTIMA META-ANALISI DALL’AUSTRALIA. DA “AP&T” (FREE).

Meta-analysis: Persistence of advanced therapies in the treatment of inflammatory bowel disease Tsz Hong Yiu et al. Abstract Background: The expanding options in advanced therapies for ulcerative colitis (UC) and Crohn’s disease (CD) present challenges in treatment selection. Persistence analysis assesses drug durability in real-world settings, acting as a surrogate marker for medication efficacy and tolerance.…

ATTENZIONE ! I SINTOMI LARINGOFARINGEI IN SOSPETTA MALATTIA DA REFLUSSO POSSONO REAGIRE ALLA LOGOTERAPIA! DA “AMERICAN JOURNAL OF GASTROENTEROLOGY”.

Laryngeal Recalibration Therapy Improves Laryngopharyngeal Symptoms in Patients with Suspected Laryngopharyngeal Reflux Disease. Erin Walsh et al. BACKGROUND: Laryngopharyngeal symptoms such as cough, throat clearing, voice change, paradoxic vocal fold movement or laryngospasm are hyper-responsive behaviors resulting from local irritation (e.g., refluxate) and heightened sympathetic tone. Laryngeal recalibration therapy (LRT) guided by a speech-language pathologist (SLP)…

HBV: LE ULTIME NOTIZIE SULLA TERAPIA. UNA OTTIMA, RAPIDA REVIEW DA HONG-KONG. DA “CLINICAL LIVER DISEASE (AASLD)” (FREE)

Therapeutic advances in HBV cure Rex Wan-Hin Hui et al. INTRODUCTION Despite efforts in hepatitis control, chronic HBV infection remains a major cause of liver-related morbidity and mortality globally.[1] HBV integration into the human genome and covalently closed circular DNA persistence are barriers to the sterilizing cure of HBV.[1] Functional cure, defined as sustained HBsAg…

E’ OPPORTUNO UN MODELLO A “FIXED-EFFECT” O A “RANDOM EFFECT” PER LA TUA META-ANALISI? UNA GRANDE, RAPIDA “SPIEGA” DA GORDON GUYATT! DAL “CHINESE MEDICAL JOURNAL” /FREE)

Fixed-effect and random-effects models in meta-analysis Zhai, Chunjuan; Guyatt, Gordon A systematic review synthesizes evidence addressing a structured clinical question using systematic and explicit methods to search, identify, screen, critically appraise, and extract and analyze data from relevant studies.[1] A meta-analysis, on the other hand, is a statistical method that combines the quantitative results of available…