EPATITE ACUTA DA FARMACI : UNA GRANDE MAPPA DEI FARMACI RESPONSABILI DALLA REAL-WORLD ANALISI SU 8 MILIONI DI PAZIENTI. DA “JAMA NETWORK” (FREE) NB: ANDATE ALLE TAVOLE SUPPLEMENTARI !

EPATOLOGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, NEWSLETTER, Senza categoria

Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data Jessie Torgersen et al. Key PointsQuestion  What are the most hepatotoxic medications based on real-world rates of severe acute liver injury and how do these rates compare with hepatotoxicity categorization based on published case reports? Findings  This series of cohort studies among 7 899 888 persons without liver or…

MASH (metabolic dysfunction-associated steatohepatitis) E FIBROSI. ATTENZIONE AL NUOVO TRIAL DELLA SURVODUTIDE. DA “NEJM”

DIAGNOSTICA PER IMMAGINI, EPATOLOGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, NEWSLETTER, Senza categoria

A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis Arun J. Sanyal, E. Bugianesi et al. per the 1404-0043 Trial Investigators Abstract BACKGROUND Dual agonism of glucagon receptor and glucagon-like peptide-1 (GLP-1) receptor may be more effective than GLP-1 receptor agonism alone for treating metabolic dysfunction–associated steatohepatitis (MASH). The efficacy and safety of…

LA CONSENSUS ITALIANA SULLA GESTIONE DELLE RACCOLTE LIQUIDE DEL PANCREAS GUIDATA DA G.CAPURSO. PARTE PRIMA. DA “DIGESTIVE AND LIVER DISEASE”

DIAGNOSTICA PER IMMAGINI, ECOGRAFIA ED ECOENDOSCOPIA, GASTROENTEROLOGIA, NEWSLETTER, PANCREAS E VIE BILIARI, Senza categoria

The i-EUS consensus on the management of pancreatic fluid collections – Part 1 Gabriele Capurso et al. PER IL GRUPPO i-EUS Pancreatic fluid collections (PFCs), including pancreatic pseudocysts (PPs) and walled-off pancreatic necrosis (WON), are common complications of pancreatitis and pancreatic surgery. Historically, the treatment of these conditions has relied on surgical and radiological approaches;…

INTERVENTO CHIRURGICO PER ULCERA PEPTICA PERFORATA: LA MORTALITA’ (9.3%) E LA MORBIDITA’ (48.5%) A 30 GG RIMANGONO ELEVATE. UN GRANDE STUDIO INTERNAZIONALE DA “SURGICAL ENDOSCOPY”

CHIRURGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, NEWSLETTER, Senza categoria

Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study Mohamed Abouelazayem et al per il gruppo GRACE Abstract Background There is little international data on morbidity and mortality of surgery for perforated peptic ulcer (PPU). This study aimed to understand the global 30-day morbidity and mortality of patients undergoing surgery for…

COLITE ULCEROSA ACUTA. I TRIAL IN CORSO: COSA CI ASPETTA! DA “GUT”

ENDOSCOPIA, GASTROENTEROLOGIA, IBD, NEWSLETTER, Senza categoria

Acute severe ulcerative colitis trials: the past, the present and the future Sailish Honap et al. Abstract Acute severe ulcerative colitis (ASUC), characterised by bloody diarrhoea and systemic inflammation, is associated with a significant risk of colectomy and a small risk of mortality. The landmark trial of cortisone in 1955 was pivotal for two reasons:…

RISANKIZUMAB VS USTEKINUMAB NEL CROHN. IL GRANDE TRIAL MULTICENTRICO “SEQUENCE”. NELLA REMISSIONE ENDOSCOPICA VINCE RISANKIZUMAB. DA “NEJM”

ENDOSCOPIA, GASTROENTEROLOGIA, IBD, NEWSLETTER, Senza categoria

Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn’s Disease L. Peyrin-Biroulet et al for the SEQUENCE Study Group. Abstract The efficacy and safety of risankizumab as compared with ustekinumab in patients with Crohn’s disease are unknown. METHODS In this phase 3b, multicenter, open-label, randomized, controlled trial with blinded assessment of end points, patients with moderate-to-severe Crohn’s disease…