CISTI PANCREATICHE: UNA SPLENDIDA REVIEW DA “NEJM” (FREE)

Pancreatic Cysts Tamas A. Gonda, et al. Cystic lesions of the pancreas were once considered to be rare and of uncertain clinical significance, as reported in the Journal in 1934.1 Over subsequent decades, these lesions came to be recognized as more common than previously thought and potentially premalignant entities that warrant concern. Imaging studies have shown a prevalence…

LO STAGING CLINICO PER IL CARCINOMA PANCREATICO TENDE CLAMOROSAMENTE A SOTTOSTIMARE LO STADIO I E II PDAC. UNA IMPORTANTE LETTER DA “JAMA” SU 58.000 PAZIENTI. (FREE)

Accuracy of Clinical Staging in Early-Stage Pancreatic Ductal Adenocarcinoma Gerardo Perrotta et al.  The survival of patients with pancreatic ductal adenocarcinoma (PDAC) correlates with its pathologic stage, ranging from 3% in stage 4 (metastatic)1 to 83.7% in stage IA.2 Preoperative imaging, used in staging, underestimates lymph node involvement3 and may lead to inaccuracy, especially in early…

PROTESI BILIARE: SFINTEROTOMIA O NO? UNA BUONA META-ANALISI: AUMENTA IL RISCHIO DI EMORRAGIA? DA “GIE”

The addition of endoscopic sphincterotomy to biliary stent placement and its impact on the risk of adverse events: an updated meta-analysis of randomized controlled trials Otavio Cosendey Martins et al. Abstract Background and Aims Endoscopic sphincterotomy (ES) is not mandatory before biliary stenting. The impact of ES before biliary stent placement remains uncertain. Previous studies…

PROTESI BILIARE: SFINTEROTOMIA O NO? PIU’ RISCHI? UN OTTIMO EDITORIALE DA “GIE” (FREE). VAI ANCHE ALLA META-ANALISI IN CODA ALL’ARTICOLO.

Role of endoscopic sphincterotomy before biliary stent placement: More risks than benefits? Sahib Singh, MD Abbreviations ES (endoscopic sphincterotomy) PEP (post-ERCP pancreatitis) RCT (randomized controlled trial) SEMS (self-expandable metallic stent) Endoscopic sphincterotomy (ES), performed during ERCP, involves incision of the circumferential muscle within the sphincter of Oddi to facilitate biliary drainage. ES is indicated in patients with postsurgical biliary adverse events…

BIOLOGICI E SMALL MOLECULES NELLA COLITE ULCEROSA. UNA MAGNIFICA REVISIONE CON NETWORK META-ANALISI. UPADACITINIB IN TESTA (QUANTI STUDI ANCORA VS PLACEBO!) DA “INFLAMMATORY BOWEL DISEASES”

Comparative Efficacy of Biologics and Small Molecule Therapies in Improving Patient-Reported Outcomes in Ulcerative Colitis: Systematic Review and Network Meta-Analysis Mohammad Shehab, MD et al. Background: Ulcerative colitis (UC) is a chronic disorder with a considerable negative impact on health-related quality of life (HRQoL), which has been recently recognized as an important treatment target. The…