IBD: LA ASSEGNAZIONE AL GRUPPO PLACEBO DANNEGGIA IL PAZIENTE ASSEGNATO AL PLACEBO NEI TRIAL ? UNO SPLENDIDO EDITORIALE SULLE META-ANALISI DI SETTORE. DA “THE LANCET” (FREE)

CHIRURGIA, GASTROENTEROLOGIA, IBD, NEWSLETTER, Senza categoria

Do placebos harm patients in IBD trials? In 1955, Truelove and Witts published the first placebo-controlled, randomised clinical trial in inflammatory bowel disease (IBD), which showed the superiority of cortisone for the treatment of acute ulcerative colitis. In the acute phase of the trial there were more deaths in the placebo group than the active…

L’ILLUSIONE DI COMPRENDERE MEGLIO CON L’INTELLIGENZA ARTIFICIALE. UN GRANDE MONITO DA “NATURE”. RIFLETTETE, GENTE, RIFLETTETE!

METODOLOGIA, NEWSLETTER, REAL WORLD EVIDENCE, Senza categoria

Artificial intelligence and illusions of understanding in scientific research Lisa Messeri & M. J. Crockett Scientists are enthusiastically imagining ways in which artifcial intelligence (AI) tools might improve research. Why are AI tools so attractive and what are the risks of implementing them across the research pipeline? Here we develop a taxonomy of scientists’ visions for…

ATTENZIONE ! PRIMARY BILIARY CHOLANGITIS: ARRIVA SELADELPAR IN SECONDA LINEA (a peroxisome proliferator–activated receptor delta agonist). UN TRIAL FASE 3 DA “THE NEW ENGLAND JOURNAL OF MEDICINE”

EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, NEWSLETTER, Senza categoria

A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis Gideon M Hirschfield et al. Abstract Background: Effective treatments for patients with primary biliary cholangitis are limited. Seladelpar, a peroxisome proliferator-activated receptor delta agonist, has potential benefits. Methods: In this phase 3, 12-month, double-blind, placebo-controlled trial, we randomly assigned (in a 2:1 ratio) patients who had had…

CANCRO DEL PANCREAS NON RESECABILE: E’ MEGLIO LA ABLAZIONE CON RADIOTERAPIA O CON ELETTROPORATION ? DA ” THE LANCET GASTROENTEROLOGY & HEPATOLOGY”

CHIRURGIA, GASTROENTEROLOGIA, NEWSLETTER, ONCOLOGIA, PANCREAS E VIE BILIARI, Senza categoria

MRI-guided stereotactic ablative body radiotherapy versus CT-guided percutaneous irreversible electroporation for locally advanced pancreatic cancer (CROSSFIRE): a single-centre, open-label, randomised phase 2 trial. Florentine E F Timmer, MD  et al. Summary Background Pancreatic ductal adenocarcinoma is an aggressive disease with a dismal prognosis. Stage III locally advanced pancreatic cancer is considered unresectable and current palliative…

OSTRUZIONE BILIARE NEOPLASTICA: LA RADIOFREQUENZA ENDOLUMINALE CON STENTING MIGLIORA LA SOPRAVVIVENZA RISPETTO AL SOLO STENTING. UNA OTTIMA META-ANALISI ! DA”ENDOSCOPY”

CHIRURGIA, ENDOSCOPIA, GASTROENTEROLOGIA, ONCOLOGIA, PANCREAS E VIE BILIARI

Endoluminal radiofrequency ablation with stenting versus stenting alone in patients with malignant biliary obstruction: a meta-analysis of randomized trials Daryl Ramai , Marcello Maida et al. Abstract Background: Endoluminal radiofrequency ablation (RFA) is a palliative treatment for patients suffering from malignant biliary obstruction (MBO). We aimed to conduct a meta-analysis to evaluate the impact of RFA on…

MA L’INTELLGENZA ARTIFICIALE MIGLIORA O NO LA “DETECTION RATE” DEGLI ADENOMI DEL COLON? UNA OTTIMA META-ANALISI. LA RISPOSTA E’ SI PER GLI ADENOMI E NO PER IL POLIPI SESSILI SERRATI. DA “GASTROINTESTINAL ENDOSCPY” (FREE)

CHIRURGIA, DISPEPSIA, ECOGRAFIA ED ECOENDOSCOPIA, GASTROENTEROLOGIA, NEWSLETTER

Use of artificial intelligence improves colonoscopy performance in adenoma detection: a systematic review and meta-analysis Jonathan Maka et al. Abstract Background and Aims Artificial intelligence (AI) is increasingly used to improve adenoma detection during colonoscopy. This meta-analysis aimed to provide an updated evaluation of computer-aided detection (CADe) systems and their impact on key colonoscopy quality indicators.…