GESTIONE DELLA TROMBOSI DELLA VENA PORTA. AGGIORNAMENTO DALL’AMERICAN GASTROENTEROLOGY ORGANIZATION FEBBRAIO 2025. “GASTROENTEROLOGY” (FREE)

CHIRURGIA, EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, NEWSLETTER, Senza categoria

AGA Clinical Practice Update on Management of Portal Vein Thrombosis in Patients With Cirrhosis: Expert Review Jessica P.E. Davis et al. Abstract Description Portal vein thromboses (PVTs) are common in patients with cirrhosis and are associated with advanced portal hypertension and mortality. The treatment of PVTs remains a clinical challenge due to limited evidence and competing…

SORVEGLIANZA PER L’HCC IN CORSO DI CIRROSI: FINE DEL MONOPOLIO DELL’ALFAFETOPROTEINA! L’EDITORIALE DA “GASTROENTEROLOGY” (FREE)

CHIRURGIA, DIAGNOSTICA PER IMMAGINI, ECOGRAFIA ED ECOENDOSCOPIA, EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, MEDICINA INTERNA, NEWSLETTER, Senza categoria

Surveillance for Hepatocellular Carcinoma in Cirrhosis: End of Monopoly for Serum Alpha Fetoprotein Lung-Yi Mak ∙ Man-Fung Yuen Hepatocellular carcinoma (HCC) is the final common pathway for all chronic liver diseases. HCC surveillance strategies are aimed at early detection to improve survival after a cancer diagnosis. The essence of HCC surveillance consists of 6-monthly ultrasonography of the liver, whereas…

OLTRE L’ALFAFETOPROTEINA: IL”GALAD” HA UN’ACCURATEZZA SUPERIORE PER LA DIAGNOSI DI CARCINOMA EPATOCELLULARE IN CORSO DI CIRROSI. DA “GASTROENTEROLOGY” (FREE)

ECOGRAFIA ED ECOENDOSCOPIA, EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, MEDICI DI FAMIGLIA, MEDICINA INTERNA, NEWSLETTER, Senza categoria

A Phase 3 Biomarker Validation of GALAD for the Detection of Hepatocellular Carcinoma in Cirrhosis Tracey L. Marsh et al Abstract Background & Aims Better surveillance tests for hepatocellular carcinoma (HCC) are needed. The GALAD score (gender, age, α-fetoprotein [AFP] L3, AFP, and des-γ carboxyprothrombin) has been shown to have excellent sensitivity and specificity for HCC…

“PUBBLICARE O MORIRE”. SI TRATTA DI UN DISASTRO, AVVERTE “NATURE”. CHI PENSA MAI ALLA RIPRODUCIBILITA’, IL VERO TEST PER LA ATTENDIBILITA’ DI UN PAPER ? (FREE)

GASTROENTEROLOGIA, MEDICINA INTERNA, METODOLOGIA, NEWSLETTER, Senza categoria

‘Publish or perish’ culture blamed for reproducibility crisis Survey of more than 1,600 biomedical researchers also flagged small sample sizes and cherry-picking of data as leading causes of reproducibility problems Laurie Udesky Nearly three-quarters of biomedical researchers think there is a reproducibility crisis in science, according to a survey published in November. The leading cause…

PICCOLE METASTASI EPATICHE DA CANCRO DEL COLON: ATTENZIONE! ESISTE UN RUOLO PER LA ABLAZIONE TERMICA INVECE DELLA CHIRURGIA! LEGGI IL TRIAL DI NON INFERIORITA’ DA ” LANCET ONCOLOGY”

CHIRURGIA, DIAGNOSTICA PER IMMAGINI, ECOGRAFIA ED ECOENDOSCOPIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, NEWSLETTER, Senza categoria

Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial Susan van der Lei, et al. Summary Background For patients with small-size colorectal liver metastases, growing evidence suggests thermal ablation to be associated with fewer adverse events and faster recovery than resection while also challenging resection…

MALATTIA DI CROHN: MA QUALE E’ LA RISPOSTA AL PLACEBO ATTRAVERSO TUTTI I TRIAL? UNA IMPRESSIONANTE META-ANALISI SU DATI INDIVIDUALI. DA “GASTROENTEROLOGY” (FREE)

GASTROENTEROLOGIA, IBD, NEWSLETTER, Senza categoria

Placebo Rates in Crohn’s Disease Randomized Clinical Trials: An Individual Patient Data Meta-Analysis Virginia Solitano et al. Abstract Background & Aims Understanding placebo rates is critical for efficient clinical trial design. We assessed placebo rates and associated factors using individual patient data from Crohn’s disease trials. Methods We conducted a meta-analysis of phase 2/3 placebo-controlled trials…