COME PREDIRE LE MALATTIE (INCLUSE LE NEOPLASIE DEL TRATTO DIGESTIVO). IL MODELLO DELPHI-2 PUO’ ANTICIPARE 1.000 MALATTIE. IL NUOVO PARADIGMA DELLA PREVENZIONE CON L’IA DA DATABASE SU 2 MILIONI DI INDIVIDUI EUROPEI. L’ARTICOLO MONSTRE DA “NATURE” (FREE) LEGGETELO!

Learning the natural history of human disease with generative transformers Artem Shmatko et al. Abstract Decision-making in healthcare relies on understanding patients’ past and current health states to predict and, ultimately, change their future course1,2,3. Artificial intelligence (AI) methods promise to aid this task by learning patterns of disease progression from large corpora of health…

INTELLIGENZA ARTIFICIALE E PREVENZIONE DELLE MALATTIE : IL SISTEMA DELPHI-2. UN COMMENTO DI BENANTI SU “L’AVVENIRE” (FREE)

Intelligenza artificiale. L’oracolo digitale “vede” le malattie in anticipo di 20 anni Paolo Benanti sabato 27 settembre 2025 Secondo quanto pubblicato da Nature la scorsa settimana, una nuova svolta nell’ambito dell’intelligenza artificiale (IA) medica promette di trasformare la medicina preventiva. Un sistema di IA modificato, denominato Delphi-2M, è ora in grado di analizzare i dati medici e gli stili…

IL MICROBIOMA ORALE E’ UN FATTORE DI RISCHIO PER IL CANCRO DEL PANCREAS! OCCHIO AL P gingivalis, E nodatum, e P micra PERIODONTALE! UN ENORME STUDIO OSSERVAZIONALE AMERICANO SU 122.000 INDIVIDUI. DA “JAMA ONCOLOGY”

Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer Yixuan Meng, PhD1,2; Feng Wu, PhD1,2; Soyoung Kwak, PhD1,2et al Key Points Question  Is the prediagnostic oral bacterial and fungal microbiome associated with the subsequent development of pancreatic cancer? Findings  In this cohort study including 122 000 individuals, 3 oral bacterial periodontal pathogens, an additional 20 bacteria, and 4 fungi were identified, which together conferred…

LA next-generation sequencing (NGS) AUMENTA LA SENSIBILITA’ PER LA DIAGNOSI DI COLANGIOCARCINOMA IN CORSO DI STENOSI BILIARI SOSPETTE. UN OTTIMO STUDIO RETROSPETTIVO OLANDESE DA “ENDOSCOPY” (FREE)

Yield of next-generation sequencing in diagnostic workup up of suspicious biliary stricture Tina L. N. Meijering et al. Abstract: Background and study aims This study addressed the need for improved diagnostic tools to identify malignancy in suspicious biliary strictures. Traditional cytological morphology is often indecisive, prompting exploration of next-generation sequencing (NGS) for enhanced sensitivity. Our…

INCONTINENZA FECALE NELL’ADULTO. OCCHIO ALLE NUOVE TERAPIE! DA”AJG” (FREE)

Fecal Incontinence in Adults: New Therapies Blackett, John W. MD, MS1; Bharucha, Adil E. MBBS, MD ABSTRACT Fecal incontinence (FI) is the involuntary and recurrent loss of stool. FI significantly affects both physical and social well-being, while imposing a substantial economic burden. The global prevalence of FI is approximately 8%. Risk factors include advanced age,…

CHIRURGIA BARIATRICA. IL PAZIENTE PUO’ TORNARE PRESTO AL LAVORO. UNA BUONA REVIEW SISTEMATICA DA “JAMA SURGERY” (FREE)

Bariatric Surgery, Employment, and Productivity Outcomes. A Systematic Review Qing Xia et al. Key Points Question  What is the impact of bariatric surgery on employment and productivity outcomes? Findings  In this systematic review of 42 studies, bariatric surgery demonstrates positive impact on work productivity and short-term work return. However, the long-term employment rate followed a reversed U-shape…