BIOPSIA EPATICA OGGI: UNO STUDIO DI REAL WORLD EVIDENCE

Liver biopsy in the real world—reporting, expert concordance and correlation with a pragmatic clinical diagnosis Hannah P. Kim et al. Summary Background: Patients with non-alcoholic steatohepatitis (NASH) and fibrosis stage ≥2 comprise a target population for pharmacotherapy. Liver biopsy, the reference standard for identifying this population, requires complete and accurate assessment of steatohepatitis and fibrosis.…

COME FUNZIONANO I VACCINI ANTI COVID-19: UNA GRANDE ARTICOLO DA NATURE

How protein-based COVID vaccines could change the pandemic Jabs from Novavax and other biotech firms are coming. Scientists say they have a lot to offer. Elie Dolgin Pamela Sherry is eager to become immunized against COVID-19. But she has put off getting a jab. “I believe vaccines work,” she says. “I want the protection.” Yet…

COME INTERPRETARE L’HAZARD RATIO : UN’OTTIMA SPIEGAZIONE PER SPIEGARE RISCHI E VANTAGGI

Come interpretare nella pratica il valore dell’ Hazard Ratio? gianfranco L’Hazard ratio (HR) è una delle misure che nella ricerca clinica spesso sono più difficili da interpretare per studenti e ricercatori. Ogni volta che mi capita di assistere un non-statistico che ha un’analisi di sopravvivenza da gestire o un paper da scrivere, al citare dell’HR…

INSUFFICIENZA EPATICA SU CRONICA : UNA LINEA GUIDA RIPRESA DA JAMA

Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU Xuan Han, MD, MS; Andrew M. Davis, MD, MPH; William F. Parker, MD, PhD GUIDELINE TITLE Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations RELEASE DATE February 14, 2020 DEVELOPER AND FUNDING…

OLTRE LE LINEE GUIDA: MA TU PRESCRIVI ASPIRINA PER LA PREVENZIONE PRIMARIA DEGLI EVENTI CARDIOVASCOLARI ? DAL BETH ISRAEL

Would You Recommend Aspirin to This Patient for Primary Prevention of Atherosclerotic Cardiovascular Disease? Grand Rounds Discussion From Beth Israel Deaconess Medical Center Risa B. Burns, MD et al. Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in the United States. Reducing ASCVD risk through primary prevention strategies has been shown to be…

I LIMITI DI CONFIDENZA: UNA RIFLESSIONE SE I RISULTATI NON SONO SIGNIFICATIVI

Use of Confidence Intervals in Interpreting Nonstatistically Significant Results Alexander T. Hawkins, MD, MPH; Lauren R. Samuels, PhD The goal of much of medical research is to determine which of 2 or more therapeutic approaches is most effective in a given situation. The power of a study is the probability of detecting a true treatment…