OCCHIO! BREAKING NEWS! K PANCREAS: PRIMO VACCINO CONTRO KRAS MUTANTE IN 20 PAZIENTI AD ALTO RISCHIO. DA ” CANCER DISCOVERY ” (FREE!)

CHIRURGIA, GASTROENTEROLOGIA, INTERNATIONAL SNAPSHOTS, NEWSLETTER, ONCOLOGIA, PANCREAS E VIE BILIARI

First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts S Daniel Haldar et al. Abstract Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a minority of precursors. Mutant KRAS (mKRAS) is present in most PDACs…

META-ANALISI: SONO TUTTE CREDIBILI? MAH! LEGGETE QUI ED APRITE ANCHE L’APPENDICE ! DA “THE LANCET”

AI, INTELLIGENZA ARTIFICIALE, GASTROENTEROLOGIA, METODOLOGIA, NEWSLETTER

What makes a meta-analysis believable? Matthew M Y Lee et al.  Introduction Meta-analysis, from Greek μετά (meta, after) and ἀνά-λυσις (ana-lysis, breaking up), refers to the analysis of analyses. Meta-analyses address what existing studies collectively allow to be inferred, rather than answering a primary research question. The use of meta-analysis has expanded rapidly, with more…

PREVENZIONE DEL K PANCREAS: LA BIOPSIA LIQUIDA. ARRIVA PANXEON! SENSIBILITA’ 87%, FALSI POSITIVI 3%. LEGGETE DA “NATURE MEDICINE”

CHIRURGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, NEWSLETTER, ONCOLOGIA, PANCREAS E VIE BILIARI

Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Caiming Xu, et al. Una nuova biopsia liquida, denominata PANXEON, ha rilevato tumori del pancreas in fase iniziale con una sensibilità dell’87%, identificando correttamente neoplasie allo stadio 1 e 2 nell’87% dei casi nell’ambito di uno studio condotto su quasi 1.800 persone. Il test ha mostrato…

STENOSI BILIARI: LE NUOVE LINEE GUIDA ESGE! DA “ENDOSCOPY” (FREE) (MEGLIO LEGGERLE!)

CHIRURGIA, DIAGNOSTICA PER IMMAGINI, ECOGRAFIA ED ECOENDOSCOPIA, ENDOSCOPIA, EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, NEWSLETTER, ONCOLOGIA, PANCREAS E VIE BILIARI

Biliary stricture management: European Society of Gastrointestinal Endoscopy (ESGE) Guideline Arnaud Lemmers et al. Abstract Main recommendations: BENIGN BILIARY STRICTURES. Main recommendations: 1: ESGE suggests temporary insertion of multiple plastic stents (MPSs) to treat postcholecystectomy benign biliary strictures. A fully covered self-expandable metal stent (FCSEMS) can be considered in these patients when the stricture is located >2…

OSTRUZIONE GASTRICA DA CANCRO: CHE FARE? CHIAMATE IL VOSTRO ECOENDOSCOPISTA! UNA IMPORTANTE META-ANALISI CON NETWORK APPROACH INTERNAZIONALE (A GUIDA ITALIANA: VIVA IL SALENTO!) DA “GIE” (FREE)

CHIRURGIA, ECOGRAFIA ED ECOENDOSCOPIA, ENDOSCOPIA, GASTROENTEROLOGIA, NEWSLETTER, NUTRIZIONE, ONCOLOGIA

Comparative efficacy and safety of treatments for malignant gastric outlet obstruction: a systematic review and network meta-analysis Mattia Brigida et al.  Abstract Background and Aims It is unclear which is the best treatment for palliation of malignant gastric outlet obstruction (GOO). We performed a network meta-analysis combining direct and indirect comparisons among the different techniques. Methods…

VARICI GASTRICHE: ATTENZIONE ALL’ULTIMA META-ANALISI INTERNAZIONALE CON NETWORK ANALYSIS GUIDATA DALL’UNIVERSITA’ DEL SALENTO! VINCE CIANOACRILATO GUIDATO DALLA ECOENDO ! OCCHIO! DA “ENDOSCOPY”

ECOGRAFIA ED ECOENDOSCOPIA, ENDOSCOPIA, EPATOLOGIA, EPATOLOGIA ONCOLOGICA, GASTROENTEROLOGIA, NEWSLETTER

Comparative efficacy and safety of endoscopic treatments for gastric varices: a systematic review and network meta-analysis Mattia Brigida et al. Abstract Background The best endoscopic treatment for gastric varices is currently unclear. We performed a network meta-analysis combining direct and indirect comparisons among the different techniques currently in use. Methods We identified 10 randomized controlled…