SANGUE OCCULTO POSITIVO E COLONSCOPIA NEGATIVA: CHE FARE ? UNA OTTIMA RIFLESSIONE E REVISIONE DEGLI STUDI DA FUCCIO E RADAELLI. DA “ENDOSCOPY”

Management after a positive fecal immunochemical test and a nonexplanatory colonoscopy: a scoping review and practical decision framework Lorenzo Fuccio , Franco Radaelli Abstract Background In fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening, colonoscopy after a positive FIT often identifies no CRC or advanced neoplasia, leaving management poorly standardized. We mapped evidence on definitions,…

CANCRO PANCREAS: LA IRRADIAZIONE ABLATIVA MASSIMALE NEI CASI LOCALMENTE AVANZATI MIGLIORA LA SOPRAVVIVENZA A PORTA A RESEZIONE. DA “JAMA SURGERY”

Maximal Ablative Irradiation Because of Encasement for Patients With Locally Advanced Pancreatic Cancer. A Nonrandomized Clinical Trial Marsha Reyngold, et al. Key Points Question  For patients with locally advanced pancreatic cancer (LAPC) with extensive arterial and venous involvement after standard chemotherapy, is ablative radiation therapy (A-RT) associated with better resectability and overall survival without undue toxicity? Findings  In…

TUMORE ESOFAGO. OTTIMA REVSIONE DI IMAGING CON TUTTE LE LINEE GUIDA ESISTENTI! DA “FRONTLINE GASTROENTEROLOGY” (FREE!)

Update on the diagnosis and management of early oesophageal squamous neoplasia Vivek C Goodoory et al. KEY MESSAGES Oesophageal squamous cell cancer remains one of the commonest causes of death due to malignancy in the world. Pathophysiology and outcomes of oesophageal squamous dysplasia differ significantly from oesophageal adenocarcinoma. Early diagnosis at endoscopy is key to…

IPERTENSIONE PORTALE: ATTENZIONE ALLE NOVITA’ GESTIONALI DA BAVENO VIII ! DA “J. OF HEPATOLOGY” (FREE!)

Baveno VIII – Advancing Consensus in Portal Hypertension Baveno VIII Faculty ABSTRACT Since the first Baveno consensus conference in 1990, successive conferences every 5 years have transformed the field of cirrhosis and portal hypertension evolving from a focus on variceal bleeding to a pathophysiology-based framework centered on risk stratification, clinically significant portal hypertension (CSPH), and…

COLANGITE PRIMARIA BILIARE: SONO APPENA USCITE LE LINEE GUIDA AISF ! DA ” DIGESTIVE & LIVER DISEASE” (FREE)

AISF practice guidance on the treatment of primary biliary cholangitis: A 2026 update Associazione Italiana per lo Studio del Fegato (AISF) Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease that, if untreated or inadequately treated, may progress to advanced fibrosis, cirrhosis, and liver-related complications. Although ursodeoxycholic acid (UDCA) remains the cornerstone…

PIATTAFORME GENERALI DI IA VS QUELLE MEDICHE SPECIALIZZATE ! DA “NATURE MEDICINE” (FREE!)

General-purpose large language models outperform specialized clinical AI tools on medical benchmarks Krithik Vishwanath et al. ATTENZIONE ! UNO STUDIO RANDOMIZZATO CON 12 MEDICI SU NATURE CONFRONTA LE PIATTAFORME GENERALI CON QUELLE MEDICHE SPECIALIZZATE (OPENEVIDENCE, UPTODATE). AND THE WINNER IS…. ______________________________________________________________________ KEY POINTS FROM IA Uno studio di giugno 2026 pubblicato su Nature Medicine ha…