DIABETE E COVID-19. UNA GRANDE REVISIONE DEL GRUPPO DI CORRAO (PA)

Type 2 Diabetes Mellitus and COVID-19: A Narrative Review Salvatore Corrao et al. The pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has involved more than one hundred million individuals, including more than two million deaths. Diabetes represents one of the most prevalent chronic conditions worldwide and significantly increases…

DIETE DI ESCLUSIONE E COLON IRRITABILE: UNA GRANDE REVISIONE EVIDENCE-BASED DI MOAYYEDI SU “NATURE GASTRO”

Evidence- based and mechanistic insights into exclusion diets for IBS Paul Moayyedi et al.       Abstract Exclusion diets are becoming increasingly popular in the management of irritable bowel syndrome (IBS). Several mechanisms exist by which food items might cause gastrointestinal symptoms, such as direct osmotic effects of food in the gut lumen, changes…

GRADE EXPERT INVITANO AD UNA CORRETTA QUANTIFICAZIONE DELLA “CERTAINTY OF EVIDENCE” . LOOK AT THE FIGURES !

GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings Linan Zeng et al. Abstract Objective : To provide practical principles and examples to help GRADE users make optimal choices regarding their ratings of certainty of evidence using a minimally or partially contextualized approach. Study Design and Setting : Based on the…

PLACEBO EFFECT: UNA GRANDE REVIEW

Pain, placebo, and test of treatment efficacy: a narrative review Lene Vase 1, Karolina Wartolowska 2 Abstract Over the past decade, the mechanisms underlying placebo effects have begun to be identified. At the same time, the placebo response appears to have increased in pharmacological trials and marked placebo effects are found in neurostimulation and surgical trials, thereby posing…

COVID-19: QUALE TERAPIA ANTI-TROMBOTICA? UNA REVISIONE DEI TRIAL DELLA ASS.AMERICANA DEI CARDIOLOGI

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 JACC State-of-the-Art Review Azita H. Talasaz et al. Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of…

LA ASSUNZIONE DI PPI RIDUCE LA RISPOSTA ALLA TERAPIA ANTI-HCV !

Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV/HCV coinfection on ledipasvir/sofosbuvir: a real‐world study from a multicentre VA cohort Tzu‐Hao Lee et al. Abstract Previous studies have reported an association of proton pump inhibitor (PPI) use and decreased sustained viral response rate (SVR) in patients taking ledipasvir/sofosbuvir (LDV/SOF). The relationship…