PLACEBO EFFECT: UNA GRANDE REVIEW

METODOLOGIA

Pain, placebo, and test of treatment efficacy: a narrative review Lene Vase 1, Karolina Wartolowska 2 Abstract Over the past decade, the mechanisms underlying placebo effects have begun to be identified. At the same time, the placebo response appears to have increased in pharmacological trials and marked placebo effects are found in neurostimulation and surgical trials, thereby posing…

COVID-19: QUALE TERAPIA ANTI-TROMBOTICA? UNA REVISIONE DEI TRIAL DELLA ASS.AMERICANA DEI CARDIOLOGI

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNA

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 JACC State-of-the-Art Review Azita H. Talasaz et al. Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of…

LA ASSUNZIONE DI PPI RIDUCE LA RISPOSTA ALLA TERAPIA ANTI-HCV !

EPATOLOGIA, GASTROENTEROLOGIA, MEDICI DI FAMIGLIA, MEDICINA INTERNA, REAL WORLD EVIDENCE

Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV/HCV coinfection on ledipasvir/sofosbuvir: a real‐world study from a multicentre VA cohort Tzu‐Hao Lee et al. Abstract Previous studies have reported an association of proton pump inhibitor (PPI) use and decreased sustained viral response rate (SVR) in patients taking ledipasvir/sofosbuvir (LDV/SOF). The relationship…

UNA OTTIMA SCHEDA DI JAMA SUI VACCINI ANTI COVID-19

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNA, REAL WORLD EVIDENCE

SARS-CoV-2 Vaccines C. Buddy Creech, MD, MPH; Shannon C. Walker, MD; Robert J. Samuels, MBChB Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its prefusion [native] conformation) was identified as the immunodominant antigen of the virus.1 Evaluation of patients with SARS-CoV-2 revealed that binding and neutralizing…

QUALE DIETA E’ ANTI-INFIAMMATORIA ?

MEDICINA DEI PROBIOTICI, NUTRIZIONE

Long-term dietary patterns are associated with proinflammatory and anti-inflammatory features of the gut microbiome Laura A Bolte et al. Abstract Objective The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions…

BREAKING NEWS : COME COMUNICARE RISCHI E BENEFICI DEL VACCINO ASTRA-ZENECA ! DALLA AGENZIA INGLESE DEL FARMACO DIAPO PER POWER POINT

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNA, METODOLOGIA, REAL WORLD EVIDENCE, Senza categoria

      MHRA issues new advice, concluding a possible link between COVID-19 Vaccine AstraZeneca and extremely rare,  unlikely to occur blood clots The benefits of vaccination continue to outweigh any risks but the MHRA advises careful consideration be given to people who are at higher risk of specific types of blood clots because of…