UN CALCOLATORE MOLTO ACCURATO PER LA PROGNOSI DEL PAZIENTE CON COVID-19

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNA, SCORE & EQUATIONS

Development of Severe COVID-19 Adaptive Risk Predictor (SCARP), a Calculator to Predict Severe Disease or Death in Hospitalized Patients With COVID-19 FREE Shannon Wongvibulsin et al. Abstract Background: Predicting the clinical trajectory of individual patients hospitalized with coronavirus disease 2019 (COVID-19) is challenging but necessary to inform clinical care. The majority of COVID-19 prognostic tools…

Più di 140,000 differenti virus vivono nell’intestino umano.

MEDICINA DEI PROBIOTICI, NUTRIZIONE

Massive expansion of human gut bacteriophage diversity Luis F. Camarillo-Guerrer et al. Highlights • Database containing 142,809 non-redundant gut phage genomes from 28,060 metagenomes • Host assignment reveals phage diversity and host range across gut bacteria isolates • Epidemiology analysis unveils 280 viral clusters that are globally distributed • The Gubaphage is a clade that…

REPLICAZIONE DEGLI STUDI CONTROLLATI NELLA “REAL WORLD EVIDENCE”: UN OTTIMO EDITORIALE

REAL WORLD EVIDENCE

Replication of Randomized, Controlled Trials Using Real-World Data: What Could Go Wrong? David Thompson1 Abstract With the growing interest in using real-world evidence (RWE) for regulatory purposes, researchers and policy makers are considering how best to assess the credibility of RWE. Because the randomized controlled trial (RCT) has long been regarded as the gold standard…

TRIAL VERSUS “REAL WORLD EVIDENCE”: THE DUPLICATE INITIATIVE. UN PRIMO CONFRONTO SU STUDI IN CARDIOLOGIA E DIABETOLOGIA

REAL WORLD EVIDENCE

Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies: First Results From the RCT DUPLICATE Initiative Jessica M Franklin et al. Abstract Background: Regulators are evaluating the use of noninterventional real-world evidence (RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE initiative (Randomized, Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques…

PER UNA MIGLIORE TRASPARENZA DEGLI STUDI DI “REAL WORLD EVIDENCE”: THE RWE TRANSPARENCY INITIATIVE

REAL WORLD EVIDENCE

Improving Transparency to Build Trust in Real-World Secondary Data Studies for Hypothesis Testing-Why, What, and How: Recommendations and a Road Map from the Real-World Evidence Transparency Initiative Lucinda S Orsin et al Abstract Real-world data (RWD) and the derivations of these data into real-world evidence (RWE) are rapidly expanding from informing healthcare decisions at the…

GLI STUDI DI “REAL WORLD EVIDENCE” PER IL DIABETE: UNA GUIDA

REAL WORLD EVIDENCE

Conducting real-world evidence studies on the clinical outcomes of diabetes treatments Sebastian Schneeweiss et al. Abstract Real-world Evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data from the routine operation of the healthcare system, is thought to complement evidence on the efficacy of medications from RCTs. RWE studies follow…