L’USO DI ANTIBIOTICI E’ FATTORE DI RISCHIO PER LO SVILUPPO DI IBD (+28-54%): UNO STUDIO DI POPOLAZIONE DANESE. DA “GUT” (FREE)

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study Adam S Faye et al. Abstract Background There is an increasing incidence of inflammatory bowel disease (IBD) for which environmental factors are suspected. Antibiotics have been associated with development of IBD in earlier generations, but their influence on IBD…

LA TERAPIA CON BIOLOGICI PER LE IBD. L’IMPATTO DELLA SEQUENZA TERAPEUTICA NELLO STUDIO INGLESE DI REAL-WORLD IN 13.222 PAZIENTI. IL RUOLO DEL VEDOLIZUMAB. DA”J Crohns Colitis”.

Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource Christina Kapizion et al. Abstract Background and aims: To compare effectiveness of different biologic therapies and sequences in patients with Inflammatory Bowel Disease (IBD) using real-world data from a large cohort with long exposure.…

ASPIRINA E PREVENZIONE DEL CANCRO. LA RECENTISSIMA REVISIONE DELLE REVISIONI E META-ANALISI! PRO E CONTRO. DA “british journal of cancer” (FREE)

Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against Peter Elwood et al. Abstract Aspirin as a possible treatment of cancer has been of increasing interest for over 50 years, but the balance of the risks and benefits remains a point of contention. We summarise the valid published evidence ‘for’ and…

FARMACOTERAPIA PER LA DIPENDENZA DA ALCOL: OCCHIO A NALTREXONE ED AL ACAMPROSATO! UNA OTTIMA META-ANALISI. DA “JAMA”

Pharmacotherapy for Alcohol Use Disorder: A Systematic Review and Meta-Analysis Melissa McPheeters et al Key Points Question  Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder? Findings  In this systematic review and meta-analysis that included 118 clinical trials and 20 976 participants, 50 mg/d of oral naltrexone and acamprosate were each associated with significantly improved…

ACUTE-ON-ON CHRONIC : INSUFFICIENZA EPATICA IN CIRROSI DA VIRUS B. TENOFOVIR OD ENTECAVIR? ATTENZIONE: MEGLIO ENTECAVIR? UNA REVISIONE CON META-ANALISI DA “BMC Gastroenterology” (FREE)

Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis Neng Wang et al Abstract Background Oral nucleoside (acid) analogues (NAs) are recommended for patients with acute-on-chronic liver failure (ACLF) associated with hepatitis B virus (HBV-ACLF). The efficacy and safety of…

DIARREA DA ACIDI BILIARI. UNA OTTIMA REVIEW CON META-ANALISI. DA “AJG” (FREE)

The Efficacy of Treatments for Bile Acid Diarrhea: A Systematic Review and Meta-Analysis Dilmaghani Saam et al.  Introduction: Irritable bowel syndrome (IBS) affects up to 15% of the population. Among pathophysiological mechanisms for diarrhea-predominant IBS (IBS-D), one-third are due to bile acid (BA) diarrhea (BAD). The mainstay of treatment is bile acid sequestrants (BAS); yet…