IL GRAVE PROBLEMA DELLA RIPRODUCIBILITA’ (Reproducibility Project: Cancer Biology): SOLO IL 26% DEGLI ESPERIMENTI PRECLINICI IN ONCOLOGIA RISULTA RIPETIBILE (FREE)

Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology Timothy M Errington et al. Abstract We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of preclinical research in cancer biology. The initial aim of the project was to repeat 193 experiments from 53 high-impact papers, using an approach in which the experimental…

IPMN (intraductal papillary mucinous neoplasms) DEL PANCREAS: UNA META-ANALISI ITALIANA DEGLI STUDI OSSERVAZIONALI CHE ATTENDEVAMO !

Systematic review and meta-analysis of observational studies on BD-IPMNS progression to malignancy lA.Balduzzi et al. Abstract Background The vast majority of presumed branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) of the pancreas are referred to a surveillance program due to the relatively low risk of malignancy. We aim to evaluate all available data from observational studies…

RIPRODUCIBILITA’: ASPETTATI MENO DALL’ARTICOLO SCIENTIFICO ! PROSEGUE LA CAMPAGNA DI “NATURE”

Reproducibility: expect less of the scientific paper Olavo B. Amaral & Kleber Neve Make science more reliable by placing the burden of replicability on the community, not on individual laboratories. In 2018, we embarked on a journey to assess the reproducibility of biomedical research papers from Brazil. Thus began a multicentre collaboration of more than 60…

MARCATORI PER IL CARCINOMA EPATOCELLULARE: IL “WHITE PAPER” DALLA INTERNATIONAL LIVER CANCER ASSOCIATION

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma Amit G. Singal et al. Biomarkers are key components of the clinical management of patients with cancer, as they have contributed to major survival improvements in these patients.1 According to the National Cancer Institute, a biomarker is a biological molecule found in…

PANCREATITE NECROTIZZANTE INFETTA : IL DRENAGGIO PRECOCE NON SEMBRA SUPERIORE AL TARDIVO. UN GRANDE TRIAL MULTICENTRICO DAL NEJM

IMMEDIATE VERSUS POSTPONED INTERVENTION FOR INFECTED NECROTIZING PANCREATITIS Lotte Boxhoorn et al. Abstract Background: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. Methods: We conducted…

DRENAGGIO PER LA PANCREATITE NECROTIZZANTE INFETTA: COME E’ DURA L’ATTESA. L’EDITORIALE DEL NEW ENGLAND OF MEDICINE

Drainage for Infected Pancreatic Necrosis — Is the Waiting the Hardest Part? Todd H. Baron, M.D. Acute necrotizing pancreatitis, which occurs in up to 30% of episodes of acute pancreatitis, can be a devastating, life-threatening disease. For many years, acute necrotizing pancreatitis (the cause of clinically severe pancreatitis) was managed with open surgical necrosectomy. Surgeons…