LE NUOVE TERAPIE BIOLOGICHE E CON “SMALL MOLECULES” PER LE IBD. UNA GRANDE REVISIONE DAL NEJM

Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease Daniel C. Baumgart et al. Crohn’s disease and ulcerative colitis, together referred to as inflammatory bowel disease (IBD), are chronic systemic inflammatory disorders.1 These conditions target primarily the gastrointestinal tract but can affect many organ systems through extraintestinal manifestations (e.g., peripheral and axial arthritis, episcleritis, primary…

COVID-19: ANCORA UNO STUDIO ” NON PEER-REVIEWED” RITIRATO DOPO 150.000 VISIONI. IL CASO IVERMECTIN SU “NATURE”

Flawed ivermectin preprint highlights challenges of COVID drug studies The study’s withdrawal from a preprint platform deals a blow to the anti-parasite drug’s chances as a COVID treatment, researchers say. Sara Reardon “Before its withdrawal, the paper was viewed more than 150,000 times, cited more than 30 times and included in a number of meta-analyses…

COVID-19: IVERMECTINA SOTTO STUDIO CON QUALCHE POLEMICA. UNA NOTA DALLA BIBLIOTECA DELLA ASSOCIAZIONE LIBERATI

Covid-19: ivermectina alla prova Pubblicato martedì 21 Settembre 2021 Sulla base delle prove attuali, non c’è sufficiente certezza sull’efficacia e la sicurezza dell’ivermectina per trattare o prevenire il covid-19. Questo in base a una revisione Cochrane di cui si è parlato molto nelle ultime settimane. L’ivermectina è un farmaco usato per trattare i parassiti, per esempio…

NOTE DA “GRADE”. CHE FARE SE NON ABBIAMO EVIDENZE PER DECIDERE ?

GRADE notes: How to use GRADE when there is “no” evidence? A case study of the expert evidence approach Reem A. Mustafa et al.  Abstract Objectives One essential requirement of trustworthy guidelines is that they should be based on systematic reviews of the best available evidence. The GRADE Working Group has provided guidance for evaluating…

LA CERTEZZA DELLE EVIDENZE. UNA GUIDA DA “GRADE”

GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings Linan Zeng  et al. Abstract Objective To provide practical principles and examples to help GRADE users make optimal choices regarding their ratings of certainty of evidence using a minimally or partially contextualized approach. Study Design and Setting Based on the…

I TEST STATISTICI PER L’IPOTESI NULLA. QUALCOSA DA RICORDARE ?

Hypothesis Tests Explained Angelica Lo Duca A quick overview of the concept of Hypothesis Testing, its classification in parametric and non-parametric tests, and when to use the most popular ones. Image by Author What is Hypothesis Testing According to Jim Frost, Hypothesis Testing is a form of inferential statistics that allows us to draw conclusions about…