IL GRAVE PROBLEMA DELLA RIPRODUCIBILITA’ (2): PERCHE’ LA RIFORMA SULLA RIPRODUCIBILITA’ STA FALLENDO. DA “NATURE” (FREE)

Understand the real reasons reproducibility reform fails Lack of rigour is often blamed on pressure to publish. But ethnographers can find out what truly keeps science from upping its game. Nicole C. Nelson A decade ago, the US National Institute of Neurological Disorders and Stroke convened a workshop on how to improve the rigour of…

COVID-19 ED INCERTEZZA: ASPIRINA FORSE NO!

Meta-Analysis of the Effect of Aspirin on Mortality in COVID-19 Husam M. Salah, et al. Repurposing of existing medications has widely been used in studies since the emergence of coronavirus disease 2019 (COVID-19). Besides dexamethasone in selected patients, no medical treatment to date has been shown to improve mortality in patients with COVID-19 infection. Aspirin…

COVID-19 ED INCERTEZZA: ASPIRINA SI’!

Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration Thomas F. Osborne et al. Abstract There is growing evidence that thrombotic and inflammatory pathways contribute to the severity of COVID-19. Common medications such as aspirin, that mitigate these pathways, may decrease COVID-19 mortality. This retrospective assessment was designed to quantify…

L’INCIDENZA DELLA PANCREATITE E’ IN FORTE AUMENTO: UNA REVISIONE SISTEMATICA ED UNA META-ANALISI DA GASTROENTEROLOGY

Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis Jordan P. Iannuzzi et al. Background & Aims Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing temporal trends of acute pancreatitis incidence globally.…

ESCE IL TRIAL CON IL MOLNUPIRAVIR PER OS COME ANTICOVID-19: DAL NEW ENGLAND JOURNAL OF MEDICINE DEL 16 DICEMBRE (FREE) (-50% DI RICOVERI)

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients Angélica Jayk Bernal et al. BACKGROUND New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS We conducted a phase 3, double-blind,…

LA NUOVA VIA ALLA DIAGNOSI. LEGGETE! LA INTELLIGENZA ARTIFICIALE CAMBIA IL PARADIGMA ? DA JAMA (FREE)

Next-Generation Artificial Intelligence for Diagnosis From Predicting Diagnostic Labels to “Wayfinding” Julia Adler-Milstein et al. Improving the diagnostic process is a quality and safety priority.1 With the digitization of health records and rapid expansion of health data, the cognitive demand on the diagnostician has increased. The use of artificial intelligence (AI) to assist human cognition has…