IL CONCETTO DI “NET BENEFIT” : OCCHIO A TUTTI GLI OUTCOME!

The Net Benefit of a treatment should take the correlation between benefits and harms into account Marc Buyse et al. Highlights • The assessment of benefits and harms from experimental treatments often ignores the association between outcomes • The method of generalized pairwise comparisons (GPC) takes into account the association between endpoints • A Net…

I PROBIOTICI DI PROSSIMA GENERAZIONE: UNA MAGNIFICA REVIEW ! (ANCHE CONTRO IL COVID-19?)

Next-Generation Probiotics and Their Metabolites in COVID-19 Thomas Gautier et al. Abstract: Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and gastrointestinal dysfunctions suggesting the spread of…

BREAKING NEWS: IL PAPER CHE INCOLPAVA LA RANITIDINA COME POTENZIALMENTE CARCINOGENA E’ STATO RITIRATO !

Widely Covered Paper on Ranitidine-Cancer Link Retracted Retraction Watch Staff A paper linking the use of a wildly popular drug for heartburn to cancer has been retracted after the authors concluded that their widely touted finding appears to have resulted from a hiccup in the way they conducted their testing. The 2016 article, in Carcinogenesis, has…

IL MICROBIOTA UMANO E’ CAUSA DI GRAVI DISEGUAGLIANZE SOCIALI: UNA RIFLESSIONE SU PNAS

The human gut microbiome and health inequities Katherine R. Amatoa et al. Individuals who are minoritized as a result of race, sexual identity, gender, or socioeconomic status experience a higher prevalence of many diseases. Understanding the biological processes that cause and maintain these socially driven health inequities is essential for addressing them. The gut microbiome…

UN NUOVO TEST EMATICO DA SEGUIRE PER LA DIAGNOSI PRECOCE DEL CANCRO DEL COLON: CIRCULATING TUMOR DNA (ctDNA)

Simple Blood Test to Detect Colorectal Cancer Roxanne Nelson, RN, BSN In the future, a simple blood test could be added to the options for colorectal screening and could appeal to the people currently put off by the unpleasant necessities such as collecting a fecal sample, or the bowel prep before an invasive colonoscopy. The…

TOFACITINIB FUNZIONA: RIDUZIONE DECESSI DA POLMONITE PER COVID-19 DEL 37 %

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia Patrícia O. Guimarães et al. BACKGROUND The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia are unclear. METHODS We randomly assigned, in a 1:1 ratio, hospitalized adults with Covid-19 pneumonia to receive either tofacitinib at a…