Altered Microbiota in Cirrhosis and Its Relationship to the Development of Infection Jasmohan S. Bajaj Figure 1 Changes in CDR in different groups. CDR was also stable over time, worsened with the development of the first episode of HE, and was worse in those who were subsequently hospitalized. Adapted from Journal of Hepatology.3 Copyright 2014, European…
Da Sherlock Holmes al Dr House. Analogie fra pensiero medico e metodo investigativo CLAUDIO RAPEZZI (il prof. Rapezzi, Associato di Cardiologia dell’Università di Bologna, è scomparso nell’ottobre 2022. RPM lo ricorda riportando la sua presentazione al volume “La EBM sulle orme di Sherlock Holmes”) Riassunto. Le analogie fra metodo clinico e scienza dell’investigazione sono abbondantemente presenti…
Risk Heterogeneity and the Illusion of Waning Vaccine Efficacy Michael P. Fay et al. Critical scientific questions about COVID-19 vaccines are whether the vaccine effect will wane over time, whether they will work on new variants, and whether booster shots are needed. As reports of the durability of vaccine protection become available (1–4), general scientific…
Examining the Nocebo Effect in Trials of Neuromodulators for Use in Disorders of Gut-Brain Interaction Jeremy R. Glissen Brown et al. INTRODUCTION: Nocebo effects are believed to influence the rate of reported adverse events (AE) and subject withdrawal in both the treatment and placebo groups of randomized clinical trials (RCT). Neuromodulators are commonly prescribed to…
Tutti i problemi del primo farmaco anti-Alzheimer Aducanumab ha un prezzo eccessivo, tempi di approvazione inusuali e rapporti anomali tra agenzia regolatoria e produttore SIMONE VALESINI Un ricercatore TEK IMAGE/SCIENCE PHOTO LIBRARY Per anni, l’anticorpo monoclonale Aducanumab è sembrato un farmaco destinato a fare la storia. Sul piano medico – doveva essere la prima terapia in grado…
2023 Should Be the Year We Admit the Internet Is a Failure With Hate, Rage, Bigotry, and Ignorance, the Internet’s Destroying Our Ability to Be a Civilization — When We Need it Most umair haque Image Credit: 1, 2 It’s 2023, and there’s something that’s gone badly wrong with human civilization. No, I don’t just mean the…