LA next-generation sequencing (NGS) AUMENTA LA SENSIBILITA’ PER LA DIAGNOSI DI COLANGIOCARCINOMA IN CORSO DI STENOSI BILIARI SOSPETTE. UN OTTIMO STUDIO RETROSPETTIVO OLANDESE DA “ENDOSCOPY” (FREE)

Yield of next-generation sequencing in diagnostic workup up of suspicious biliary stricture Tina L. N. Meijering et al. Abstract: Background and study aims This study addressed the need for improved diagnostic tools to identify malignancy in suspicious biliary strictures. Traditional cytological morphology is often indecisive, prompting exploration of next-generation sequencing (NGS) for enhanced sensitivity. Our…

INCONTINENZA FECALE NELL’ADULTO. OCCHIO ALLE NUOVE TERAPIE! DA”AJG” (FREE)

Fecal Incontinence in Adults: New Therapies Blackett, John W. MD, MS1; Bharucha, Adil E. MBBS, MD ABSTRACT Fecal incontinence (FI) is the involuntary and recurrent loss of stool. FI significantly affects both physical and social well-being, while imposing a substantial economic burden. The global prevalence of FI is approximately 8%. Risk factors include advanced age,…

CHIRURGIA BARIATRICA. IL PAZIENTE PUO’ TORNARE PRESTO AL LAVORO. UNA BUONA REVIEW SISTEMATICA DA “JAMA SURGERY” (FREE)

Bariatric Surgery, Employment, and Productivity Outcomes. A Systematic Review Qing Xia et al. Key Points Question  What is the impact of bariatric surgery on employment and productivity outcomes? Findings  In this systematic review of 42 studies, bariatric surgery demonstrates positive impact on work productivity and short-term work return. However, the long-term employment rate followed a reversed U-shape…

SIMVASTATINA DOPO SANGUINAMENTO DA VARICI. GRANDE TRIAL INDIANO. OCCHIO ALLA SOPRAVVIVENZA! DA”AJG”

Simvastatin Addition to Standard of Care Improves Long-Term Survival in Patients With Cirrhosis After Variceal Bleed: An Open Label Randomized Controlled Trial Randeep Rana et al. Abstract Introduction: There is limited evidence about efficacy and safety of simvastatin in decompensated cirrhosis. We assessed whether addition of simvastatin to standard of care improves long-term survival in patients…

ESOFAGO DI BARRETT: MEGLIO LA SORVEGLIANZA BIENNALE O LA ENDOSCOPIA AL BISOGNO? UN OTTIMO TRIAL CLINICO CON SORPRESA FINALE! DA “GASTROENTEROLOGY” (FREE)

Barrett’s Oesophagus Surveillance Versus Endoscopy at Need Study (BOSS): A Randomized Controlled Trial Oliver Old et al. Abstract Background & Aims Barrett’s esophagus (BE) is a precursor lesion for esophageal adenocarcinoma (EAC). Surveillance endoscopy aims to detect early malignant progression; although widely practiced, it has not previously been tested in a randomized trial. Methods BOSS (Barrett’s…

CAFFE’ PER IL FEGATO ! CONSIGLIATELO, O EPATOLOGI/GASTROENTEROLOGI! DA”Biochemical Pharmacology” (FREE)

Coffee for the liver: a mechanistic approach Eduardo E. Vargas-Pozada et al.. Abstract The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for…