DRENAGGIO DELLA COLECISTI PER VIA ECOENDOSCOPICA VERSUS COLECISTOSTOMIA PER VIA PERCUTANEA. UNA META-ANALISI CON LA TECNICA DELLA “SEQUENTIAL ANALYSIS” DAL GRUPPO DELLA EMILIA-ROMAGNA

Trial sequential analysis of EUS-guided gallbladder drainage versus percutaneous cholecystostomy in patients with acute cholecystitis AlessandroCucchetti et al. Abstract Background and Aims Meta-analytic comparison of endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) versus percutaneous gallbladder drainage (PT-GBD) for acute cholecystitis (AC) brings the risk of spurious results if too few studies are included. Trial sequential analysis (TSA)…

REGORAFENIB DOPO TACE PER CARCINOMA EPATICO NON RESECABILE: UNO STUDIO DI REAL-WORLD EVIDENCE

Regorafenib combined with transarterial chemoembolization for unresectable hepatocellular carcinoma: a real-world study Yue Han et al. Abstract Background The benefits and tolerability of transarterial chemoembolization (TACE) combined with regorafenib as a second-line therapy has not been reported for unresectable hepatocellular carcinoma (HCC). This study aimed to explore the benefits and tolerability of TACE combined with…

LE MALATTIE INFIAMMATORIE IMMUNO-MEDIATE RISPONDONO MENO AL VACCINO A mRNA ANTI COVID-19. UNA OPPORTUNA META-ANALISI DA GASTROENTEROLOGY

Serologic response to coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis Atsushi Sakuraba et al. BACKGROUND AND AIMS: Patients with immune-mediated inflammatory diseases (IMIDs) have an increased risk of COVID-19, primarily attributed to the use of immunosuppressive drugs such as glucocorticoids, which may attenuate the response to vaccines.…

REGORAFENIB E CHEMOEMBOLIZZAZIONE PER L’EPATOCARCINOMA NON RESECABILE. UNO STUDIO POSITIVO DI REAL WORLD EVIDENCE

Regorafenib combined with transarterial chemoembolization for unresectable hepatocellular carcinoma: a real-world study Yue Han et al. Abstract Background The benefits and tolerability of transarterial chemoembolization (TACE) combined with regorafenib as a second-line therapy has not been reported for unresectable hepatocellular carcinoma (HCC). This study aimed to explore the benefits and tolerability of TACE combined with…

OCCHIO AL MOLNUPIRAVIR PER OS COME ANTI COVID-19. QUALCHE RIFLESSIONE IN ATTESA DELLA APPROVAZIONE DA MEDICAL NEWS TODAY

Molnupiravir vs. COVID-19: Will the drug live up to the hype? Katharine Lang In the search for effective COVID-19 treatments, many drugs have failed to live up to their early promise. In a recent trial, seen as an important advance, the oral antiviral drug molnupiravir halved the risk of hospital admissions and deaths from COVID-19.…

COME INTERPRETARE UNA LINEA GUIDA ! DA JAMA

How to Interpret and Use a Clinical Practice Guideline or RecommendationUsers’ Guides to the Medical Literature Romina Brignardello-Petersen,et al. Abstract Importance  Clinicians may rely on recommendations from clinical practice guidelines for management of patients. Observations  A clinical practice guideline is a published statement that includes recommendations that are intended to optimize patient care. In the guideline development process,…