Nearing 5,000 retractions: A review of 2022 Retractions of a given year’s publications as a percentage of papers published in science and engineering. Retraction data from Retraction Watch Database, overall publication figures via U.S. NSF. In 2002, journals retracted 119 papers from the scientific literature. What a difference two decades make. On several occasions this…
RNA Sequencing as a Diagnostic Tool Shamika Ketkar et al. RNA sequencing (RNA-seq) is a new tool in the genetic diagnostic laboratory made possible by the advent of low-cost, high-throughput, next-generation sequencing technology. Historically, RNA studies were limited to gene expression using microarray technology for the detection of gene rearrangements and quantification of gene expression for predefined…
Anxiety Disorders: A Review Kristin L. Szuhany; Naomi M. Simon Importance Anxiety disorders have a lifetime prevalence of approximately 34% in the US, are often chronic, and significantly impair quality of life and functioning. Observations Anxiety disorders are characterized by symptoms that include worry, social and performance fears, unexpected and/or triggered panic attacks, anticipatory anxiety, and avoidance behaviors.…
Target trial emulation: applying principles of randomised trials to observational studies Anthony A Matthews et al. “using observational data to emulate a target trial” The randomised trial is the preferred study design for evaluating the effectiveness and safety of interventions. Yet such trials can be prohibitively expensive, unethical, or take too long. When…
2022’s Top 10 Gastroenterology Publications David A. Johnson, MD ‘Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis’ The WATERFALL study was an early weight-based comparison of aggressive vs nonaggressive goal-directed fluid resuscitation in the initial phase of acute pancreatitis. Patients were randomly assigned to receive intravenous (IV) fluids (lactated Ringer solution) of either aggressive (IV bolus of 20…
Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis. Maria Rosa Ingross et al. Background & Aims Although there have been multiple drugs tested in gastroparesis, their relative efficacy and safety is unknown. We evaluated this in a network meta-analysis of randomized controlled trials (RCTs). Methods We searched the literature to 7th September…