Target trial emulation: applying principles of randomised trials to observational studies Anthony A Matthews et al. “using observational data to emulate a target trial” The randomised trial is the preferred study design for evaluating the effectiveness and safety of interventions. Yet such trials can be prohibitively expensive, unethical, or take too long. When…
2022’s Top 10 Gastroenterology Publications David A. Johnson, MD ‘Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis’ The WATERFALL study was an early weight-based comparison of aggressive vs nonaggressive goal-directed fluid resuscitation in the initial phase of acute pancreatitis. Patients were randomly assigned to receive intravenous (IV) fluids (lactated Ringer solution) of either aggressive (IV bolus of 20…
Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis. Maria Rosa Ingross et al. Background & Aims Although there have been multiple drugs tested in gastroparesis, their relative efficacy and safety is unknown. We evaluated this in a network meta-analysis of randomized controlled trials (RCTs). Methods We searched the literature to 7th September…
Replicability in the context of systematic reviews: A call for a framework with considerations regarding duplication, overlap, and intentionality Livia Puljak, Dawid Pieper Letter to the editor Reproducibility and replicability are considered central to the development and evolution of science, as they should ensure the efficient generation of reliable knowledge [[1. Much has been written…
L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial Arpan Jainet al. Abstract Background and Aims: Data on the use of intravenous L-ornithine Laspartate (LOLA) in the treatment of overt HE (OHE) is limited. We evaluated the role of intravenous LOLA in patients of cirrhosis with OHE grade III–IV. Approach…
Contemporary Surgical Management of Pancreatic Necrosis Lydia R. Maurer, MD, MPH; Peter J. Fagenholz, MD Abstract Importance For decades, infected or symptomatic pancreatic necrosis was managed by open surgical necrosectomy, an approach that has now been largely supplanted by an array of techniques referred to as the step-up approach. Observations This review describes the evidence base behind the…