PER UNA MIGLIORE TRASPARENZA DEGLI STUDI DI “REAL WORLD EVIDENCE”: THE RWE TRANSPARENCY INITIATIVE

Improving Transparency to Build Trust in Real-World Secondary Data Studies for Hypothesis Testing-Why, What, and How: Recommendations and a Road Map from the Real-World Evidence Transparency Initiative Lucinda S Orsin et al Abstract Real-world data (RWD) and the derivations of these data into real-world evidence (RWE) are rapidly expanding from informing healthcare decisions at the…

GLI STUDI DI “REAL WORLD EVIDENCE” PER IL DIABETE: UNA GUIDA

Conducting real-world evidence studies on the clinical outcomes of diabetes treatments Sebastian Schneeweiss et al. Abstract Real-world Evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data from the routine operation of the healthcare system, is thought to complement evidence on the efficacy of medications from RCTs. RWE studies follow…

LIVELLI PLASMATICI DEI DOA: CHE UTILITA’ CLINICA ?

Direct Oral Anticoagulants Plasma Levels Measurement: Clinical Usefulness from Trials and Real-World Data Francesca Renon 1, et al Abstract Measurement of direct oral anticoagulants (DOACs) activity is not routinely necessary. Indeed, evaluation of DOACs plasmatic concentration is discouraged for the majority of patients, due to the lack of outcome data supporting this approach. Nevertheless, DOAC measurements…

LE 243 REVISIONI SISTEMATICHE E META-ANALISI SUL COVID-19 SONO DI QUALITA’ RIDOTTA !

Reporting and methodological quality of COVID-19 systematic reviews needs to be improved: an evidence mapping Yanfei Li et al. Abstract Objectives : To assess the reporting and methodological quality of COVID-19 systematic reviews, and to analyze trends and gaps in the quality, clinical topics, author countries, and populations of the reviews using an evidence mapping…

TOSSE ACUTA NEL BAMBINO: UNA GRANDE REVISIONE DELLA SOCIETA’ ITALIANA DI ALLERGIA PEDIATRICA ED UN ALGORITMO

Acute cough in children and adolescents: A systematic review and a practical algorithm by the Italian Society of Pediatric Allergy and Immunology Gian Luigi Marseglia et al. Abstract The current systematic review presented and discussed the most recent studies on acute cough in pediatric age. After that, the Italian Society of Pediatric Allergy and Immunology…

CANCRO GASTRICO: UNA ULTIMA REVISIONE

Current treatment and recent progress in gastric cancer Smita S Joshi, et al. Gastric cancer is not a top-10 malignancy in the United States but represents one of the most common causes of cancer death worldwide. Biological differences between tumors from Eastern and Western countries add to the complexity of identifying standard-of-care therapy based on…