Clinical advances and ongoing trials of mRNA vaccines for cancer treatment Cathrine Lund Lorentzen et al. Summary Years of research exploring mRNA vaccines for cancer treatment in preclinical and clinical trials have set the stage for the rapid development of mRNA vaccines during the COVID-19 pandemic. Therapeutic cancer vaccines based on mRNA are well tolerated,…
The tumour immune microenvironment and microbiome of pancreatic intraductal papillary mucinous neoplasms Tommaso Pollini, et al Pancreatic intraductal papillary mucinous neoplasms (IPMNs) have gained substantial attention because they represent one of the only radiographically identifiable precursors of invasive pancreatic ductal adenocarcinoma. Although most of these neoplasms have low-grade dysplasia and will remain indolent, a subset…
Obama: Internet indebolisce la democrazia Secondo l’ex presidente degli Stati Uniti servono nuove regole per contrastare la disinformazione in rete Barack Obama Barack Obama ha parlato all’università di Stanford in California sulle opportunità e i rischi di internet per la democrazia. Sono questioni molto attuali che toccano i problemi irrisolti dell’uso politico della rete e…
Comparison of Risk Scores for Lower Gastrointestinal Bleeding. A Systematic Review and Meta-analysis Majed Almaghrabi et al. Key Points Question Which risk score for lower gastrointestinal bleeding best discriminates safe discharge, major bleeding, need for transfusion, and need for hemostasis? Findings In this systematic review and meta-analysis of 9 studies of 4 risk scores, the Oakland score was…
Comparison of Society Guidelines for the Management and Surveillance of Pancreatic Cysts. A Review Hassan Aziz, et al Abstract Importance The identification of incidental pancreas cystic lesions (PCLs) has increased in recent decades with the expanded use and improved sensitivity of cross-sectional imaging. Because the overall risk of malignancy associated with PCLs is low, yet the relative…
Diagnosis and Management of Barrett’s Esophagus: An Updated ACG Guideline Shaheen, Nicholas J. et al. Abstract Barrett’s esophagus (BE) is a common condition associated with chronic gastroesophageal reflux disease. BE is the only known precursor to esophageal adenocarcinoma, a highly lethal cancer with an increasing incidence over the last 5 decades. These revised guidelines implement…